(S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-01-12 - 2017-01-13 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

by the Department of Health of the Government of the United Kingdom

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

(S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate

EC Number:

257-581-0

EC Name:

(S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate

Cas Number:

51988-14-8

Molecular formula:

C9H6N2OS3

IUPAC Name:

phenyl[(5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl)sulfanyl]methanone

Test material form:

solid: particulate/powder

Details on test material:

- Density: 1.033 g/cm³

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature

Results and discussion

Mass median aerodynamic diameter:

18.017 µm

Geometric standard deviation:

0.14

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

6.728 µm

St. dev.:

0.035

Particle size 2

Key result

Percentile:

D50

Mean:

17.727 µm

St. dev.:

0.137

Particle size 3

Key result

Percentile:

D90

Mean:

43.34 µm

St. dev.:

0.67

Particle size distribution at different passages

Particle size distribution at different passages 1

No.:

#1

Size:

< 15 µm

Distribution:

ca. 39.82 %

Particle size distribution at different passages 2

No.:

#2

Size:

< 50 µm

Distribution:

ca. 91.9 %

Particle size distribution at different passages 3

No.:

#3

Size:

< 100 µm

Distribution:

ca. 93.4 %

Applicant's summary and conclusion

Conclusions:

Particle size distribution was determined by a scientifically reasonably study according to ISO 13320:2009 and CIPAC MT 187 under GLP, so there is no reason to conclude that the results are not reliable. Particle size distribution of (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)benzenecarbothioate revealed a MMAD of 18.017 µm.

Executive summary:

The results of the laser diffraction test conducted in accordance with ISO 13320:2009 and CIPAC MT 187 to determine the particle size of (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate are summarised below. The analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.

 

Particle Size Analysis using small volume (wet) module (SVM)	Average (µm)
Volume weighted mean	27.628
Median	17.727
Mode	18.194
MMAD (mass median aerodynamic diameter)	18.017
d10 - 10 % of material is <	6.728
d50 - 50 % of material is <	17.727
d90 - 90 % of material is <	43.340
volume of sample < 10.00 µm	20.01 %