(S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2017-01-12 - 2017-01-13 (experimental phase)

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods

Qualifier:

according to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Version / remarks:

2009

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CIPAC MT 187

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

by the Department of Health of the Government of the United Kingdom

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Specific details on test material used for the study:

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature

Mass median aerodynamic diameter:

18.017 µm

Geometric standard deviation:

0.14

Key result

Percentile:

D10

Mean:

6.728 µm

St. dev.:

0.035

Key result

Percentile:

D50

Mean:

17.727 µm

St. dev.:

0.137

Key result

Percentile:

D90

Mean:

43.34 µm

St. dev.:

0.67

No.:

#1

Size:

< 15 µm

Distribution:

ca. 39.82 %

No.:

#2

Size:

< 50 µm

Distribution:

ca. 91.9 %

No.:

#3

Size:

< 100 µm

Distribution:

ca. 93.4 %

Conclusions:

Particle size distribution was determined by a scientifically reasonably study according to ISO 13320:2009 and CIPAC MT 187 under GLP, so there is no reason to conclude that the results are not reliable. Particle size distribution of (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl)benzenecarbothioate revealed a MMAD of 18.017 µm.

Executive summary:

The results of the laser diffraction test conducted in accordance with ISO 13320:2009 and CIPAC MT 187 to determine the particle size of (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate are summarised below. The analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.

 

Particle Size Analysis using small volume (wet) module (SVM)	Average (µm)
Volume weighted mean	27.628
Median	17.727
Mode	18.194
MMAD (mass median aerodynamic diameter)	18.017
d10 - 10 % of material is <	6.728
d50 - 50 % of material is <	17.727
d90 - 90 % of material is <	43.340
volume of sample < 10.00 µm	20.01 %

Description of key information

The results of the laser diffraction test conducted in accordance with ISO 13320:2009 and CIPAC MT 187 to determine the particle size of (S)-(4,5-dihydro-5-thioxo-1,3,4-thiadiazol-2-yl) benzenecarbothioate are summarised below. The analysis was conducted using the small volume (wet) module (SVM) with silicone oil as the dispersant.

 

Particle Size Analysis using small volume (wet) module (SVM)	Average (µm)
Volume weighted mean	27.628
Median	17.727
Mode	18.194
MMAD (mass median aerodynamic diameter)	18.017
d10 - 10 % of material is <	6.728
d50 - 50 % of material is <	17.727
d90 - 90 % of material is <	43.340
volume of sample < 10.00 µm	20.01 %