3,7-dimethyloctane-1,7-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1972-1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Normal, healthy rats of the Charles River strain, equally divided as to sex and weighing 200 to 300 grams, were used in this study. The animals were fasted for eighteen hours prior to dosing. The test material was fed as received. A rigid stomach tube was employed for the dosing.
Following the administration of the test material the animals were observed for fourteen days for signs of toxicity. Throughout the observation period the animals were housed in raised wire mesh cages in an air conditioned room. They were fed their regular diet of Lab Blox and water ad libitum.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctane-1,7-diol

EC Number:

203-517-1

EC Name:

3,7-dimethyloctane-1,7-diol

Cas Number:

107-74-4

Molecular formula:

C10H22O2

IUPAC Name:

3,7-dimethyloctane-1,7-diol

Test material form:

liquid

Specific details on test material used for the study:

Name: Hydroxycitronellol
Batch: E. O. A. # 72-128 / 5-25-72

Test animals

Species:

rat

Strain:

other: Charles River

Sex:

male/female

Details on test animals or test system and environmental conditions:

Normal, healthy rats of the Charles River strain, equally divided as to sex and weighing 200 to 300 grams, were used in this study. The animals were fasted for eighteen hours prior to dosing. The test material was fed as received. A rigid stomach tube was employed for the dosing.
Following the administration of the test material the animals were observed for fourteen days for signs of toxicity. Throughout the observation period the animals were housed in raised wire mesh cages in an air conditioned room. They were fed their regular diet of Lab Blox and water ad libitum.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

not further specified

Doses:

5000 mg/kg

No. of animals per sex per dose:

5 m / 5 f

Control animals:

not specified

Details on study design:

The animals were fasted for eighteen hours prior to dosing. Following the administration of the test material the animals were observed for fourteen days for signs of toxicity.

Statistics:

not further specified

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 mL/kg bw

Based on:

test mat.

Remarks on result:

not determinable due to absence of adverse toxic effects

Mortality:

The dosing caused no mortality.

Clinical signs:

The dosing caused no adverse effects.

Body weight:

The dosing caused no adverse effects.

Gross pathology:

not further specified

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Conclusions:

The LD50 was greater as 5 mL/kg bw.

Executive summary:

The single oral dosing of rats with 5 mL/kg of the test item caused no mortality or any visible toxic effects. As this dose level did not produce a toxic effect, a complete LD50 study was not performed.