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Physical & Chemical properties

Water solubility

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water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
31st October 2017 to 1st December 2017
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 105 (Water Solubility)
according to guideline
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. QA statement)
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Type of method:
flask method
Specific details on test material used for the study:
4,4'-(1,3-Phenylenediisopropylidene) diphenylcyanate
Alternative Identification:
Arocy XU 366
Appearance/Physical state:
Yellow viscous liquid
Expiry / Retest date:
29 September 2019
Storage conditions:
Approximately 4 °C, in the dark
Key result
Water solubility:
0 g/L
Conc. based on:
test mat.
40 °C
>= 6.7 - < 6.8
Details on results:
On completion of the equilibration period, the samples were clear and colorless with excess test item present at the bottom of the test vessels. The solutions were decanted, avoiding excess test item prior to centrifugation. After centrifugation, the supernatant was taken for analysis. The supernatant was visually observed to be clear/colorless and free from un-dissolved test item.
The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1x10-2 g/L. However, due to the physical nature of the test item, it was not possible to use this method; experience has shown that liquid test items coated onto glass beads cause these beads to adhere together forming a plug within the column and thus preventing water circulation.
All individual water solubility results were within ± 15% of the mean, thus satisfying the criteria specified in the guidelines.
The limit value used was calculated by the highest individual result.
The water solubility of the test item has been determined to be less than 9.5 x 10-6 g/L of solution at 20.0 ± 0.5 °C.
Executive summary:

Water Solubility. Less than or equal to 9.53 x 10-6 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A.6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

Key value for chemical safety assessment

Additional information