Registration Dossier

Administrative data

Endpoint:
skin sensitisation: in vitro
Data waiving:
other justification
Justification for data waiving:
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING
In vitro testing does not differentiate between category 1 and category 2 sensitisers so in vivo testing would be required. It is not in the interest of animal welfare to carry out LLNA testing.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1,3-Bis[2-(4-cyanatophenyl)-2-propyl]benzene
Cas Number:
127667-44-1
Molecular formula:
C26 H24 N2 O2
IUPAC Name:
1,3-Bis[2-(4-cyanatophenyl)-2-propyl]benzene
Constituent 2
Chemical structure
Reference substance name:
1,3,5-triazine-2,4,6-triyltris(oxybenzene-4,1-diylpropane-2,2-diylbenzene-3,1-diylpropane-2,2-diylbenzene-4,1-diyl) tricyanate
Molecular formula:
C78H72N6O6
IUPAC Name:
1,3,5-triazine-2,4,6-triyltris(oxybenzene-4,1-diylpropane-2,2-diylbenzene-3,1-diylpropane-2,2-diylbenzene-4,1-diyl) tricyanate
Constituent 3
Chemical structure
Reference substance name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl cyanate
Molecular formula:
C19H19NO
IUPAC Name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl cyanate
Constituent 4
Chemical structure
Reference substance name:
4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenyl N-{(E)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Molecular formula:
C52H50N4O4
IUPAC Name:
4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenyl N-{(E)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Constituent 5
Chemical structure
Reference substance name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl N-{(Z)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Molecular formula:
C45H45N3O3
IUPAC Name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl N-{(Z)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Constituent 6
Chemical structure
Reference substance name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl N-[(E)-(4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenoxy)methylidene]carbamimidate
Molecular formula:
C38H40N2O2
IUPAC Name:
4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenyl N-[(E)-(4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenoxy)methylidene]carbamimidate
Constituent 7
Chemical structure
Reference substance name:
2,4,6-tris(4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenoxy)-1,3,5-triazine
Molecular formula:
C57H57N3O3
IUPAC Name:
2,4,6-tris(4-{2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}phenoxy)-1,3,5-triazine
Constituent 8
Chemical structure
Reference substance name:
4-[2-(3-{2-[4-({4,6-bis[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]-1,3,5-triazin-2-yl}oxy)phenyl]propan-2-yl}phenyl)propan-2-yl]phenyl N-{(E)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Molecular formula:
C104H98N8O8
IUPAC Name:
4-[2-(3-{2-[4-({4,6-bis[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]-1,3,5-triazin-2-yl}oxy)phenyl]propan-2-yl}phenyl)propan-2-yl]phenyl N-{(E)-[4-(2-{3-[2-(4-cyanatophenyl)propan-2-yl]phenyl}propan-2-yl)phenoxy]methylidene}carbamimidate
Constituent 9
Reference substance name:
Polymeric impurites: reaction product of Bishenol M with cyanogen bromide
Molecular formula:
not available
IUPAC Name:
Polymeric impurites: reaction product of Bishenol M with cyanogen bromide
Details on test material:
Identification: Sodium benzoate
Purity: >99.5%
Physical state/Appearance: white granular solid
Expiry Date: 09 May 2022
Storage Conditions: room temperature over silica gel

Results and discussion

Applicant's summary and conclusion