Registration Dossier
Registration Dossier
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EC number: 245-904-8 | CAS number: 23843-64-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to the attached justification in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 220 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Reference
Description of key information
ErC50 (72 h) > 220 mg/L (nominal, OECD 201, RA CAS No. 116912 -64 -2)
NOErC (72 h) = 10 mg/L (nominal, OECD 201, RA CAS No. 116912 -64 -2)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 220 mg/L
- EC10 or NOEC for freshwater algae:
- 10 mg/L
Additional information
No reliable data on the toxicity of 1-[3 -(trimethoxysilyl)propyl]urea (CAS No. 23843 -64 -3) to algae are available. Therefore, good quality data for the analogous substance, ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2), have been read across. Details on the read across can be found in IUCLID Section 13.
The influence of the read across substance ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (CAS No. 116912-64-2) on the growth of the freshwater algae species Pseudokirchneriella subcapitata was investigated in a 72 h static test according to OECD 201 guidance and GLP standards (2000). Test item concentrations of 0 (control), 10, 22, 46, 100 and 220 mg/L were used. The test item concentrations in the media were analytically verified using MS detection. The substance degraded rapidly within 72 h due to hydrolysis. The study resulted in an ErC50 of > 220 mg/L and a NOErC (72 h) of 10 mg/L. Considering the fast hydrolytical degradation of the substance it is assumed that the test organisms were exposed to both parent and hydrolysis products during the test. Comparable results are expected for the target substance 1 -[3 -(trimethoxysilyl)propyl]urea (CAS No. 23843 -64 -3).
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