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Water solubility

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Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24.5.-11.9.2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was performed by following the recommended methods (Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995) and GLP.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
GLP compliance:
yes (incl. QA statement)
Remarks:
Certificate is included in the study report
Type of method:
flask method
Water solubility:
< 0.51 µg/L
Temp.:
20 °C
pH:
>= 6.24 - <= 6.49
Remarks on result:
other: T = 20.0 ± 0.5 °C
Details on results:
All the sample solutions' analyte concentrations in the main test were below the detection limit of 5.10 x 10^-7 g/L (20.0 ± 0.5 °C).
Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)

During the preliminary study the water solubility of the test item was estimated to be < 0.005 mg/L. Method A6 Water solubility (440/2008/EC) recommends that the column elution method should be used if the water solubility is < 1x10^-2 g/L. However, since the substance is insoluble in organic solvents, the column elution method could not be applied.

In the main test using the flask method, it was found that the signals of the sample solutions were below the limit of detection (LOD = 5.10 x 10^-7 g/L). The substance is therefore very poorly soluble in water.
Executive summary:

The water solubility of the substance was determined to be less than 5.10 x 10^-7 g/L of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24.5.-11.9.2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was performed by following the recommended methods (Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995) and GLP.
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The flask method was used even though the method recommends the column elution method for test items with a solubility < 10 mg/L.
GLP compliance:
yes (incl. QA statement)
Remarks:
Certificate is included in the study report
Type of method:
flask method
Water solubility:
<= 7.43 µg/L
Temp.:
20 °C
pH:
ca. 6.5
Remarks on result:
other: T = 20.0 ± 0.5 °C
Details on results:
Based on the titanium concentration in the samples of the main test the results are the following:
Mean Concentration : 4.66 x 10^-6 g/L at 20.0 ± 0.5 ºC
Range : 5.62 x 10^-7 to 7.43 x 10^-6 g/L
Standard Deviation : 3.62 x 10^-6
Overall Result : ≤ 7.43 x 10^-6 g/L (as titanium) at 20.0 ± 0.5 ºC.

The titanium concentration (g/L) in the sample solutions is shown in the following table:

Sample Number

Time Shaken at ~ 30 ⁰C (hours)

Time Equilibrated at 20 ⁰C (hours)

Titanium concentration

(g/L)

Mean titanium

concentration

(g/L)

Solution pH

1A

24

24

6.13 x 10^-6

5.98 x 10^-6

6.49

1B

24

24

5.83 x 10^-6

2A

48

24

7.41 x 10^-6

7.43 x 10^-6

6.49

2B

48

24

7.45 x 10^-6

3A

72

24

4.30 x 10^-7

5.62x 10^-7   

6.51   

 3B 72  24 

6.94 x 10^-7

Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)

During the preliminary study the water solubility of the test item was estimated to be < 0.005 mg/L. Method A6 Water solubility (440/2008/EC) recommends that the column elution method should be used if the water solubility is < 1x10^-2 g/L. However, since the substance is insoluble in organic solvents, the column elution method could not be applied.

The water solubility of the test item in the main test using the flask method has been determined to be less than or equal to 7.43 x 10^-6 g/L of solution at 20.0 ± 0.5 °C. The substance is therefore very poorly soluble in water.
Executive summary:

The water solubility of the substance was determined to be less than or equal to 7.43 x 10 ^-6 g/L (as titanium) of solution at 20.0 ± 0.5 °C, using the flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.

Description of key information

Flask method: water solubility <0.51 µg/L at 20 °C (EU Method A6 and OECD 105 with slight deviations, GLP) 

Key value for chemical safety assessment

Water solubility:
0.51 µg/L
at the temperature of:
20 °C

Additional information

During the preliminary study the water solubility of the sodium form test item was estimated to be < 0.005 mg/L. Method A6 Water solubility (440/2008/EC) recommends that the column elution method should be used if the water solubility is < 1x10^-2 g/L. However, since the substance is insoluble in organic solvents, the column elution method could not be applied.

 

Using the flask method, the sample solution signals in the main test with the sodium form were below the limit of detection (LOD = 5.10 x 10^-7 g/L). Similarly, the water solubility of the sodium/hydrogen form was determined to be less than or equal to 7.43 x 10^-6 g/L. The substance is therefore very poorly soluble in water.