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EC number: 203-423-0 | CAS number: 106-68-3
The study was performed to assess the irritancy potential of methyl n-amyl ketone to the eye of the New Zealand White rabbit. The method was designed to be compatible with OECD TG 405 and EC No. 440/2008 Method 85. Three rabbits were exposed to 0.1 mL of the undiluted substance. A single application of the test item to the non-irrigated eye of three rabbits produced moderate conjunctival irritation. One treated eye appeared normal at the 48-hour observation and two treated eyes appeared normal at the 72-Hour observation. As the effects were fully reversible, no corneal opacity or iritis was observed, and conjunctival effects of grade 2 were observed at 24h in one animal only, methyl n-amyl ketone does not need to be classified for eye irritation in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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