Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27-01-2017 / 08-02-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient - HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Remarks:
colorless
Details on test material:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Test item 207812/A, Batch No: EM14089719
- Purity 99.9%
- Expiration date of the lot/batch: 1 August 2017
- Purity test date: 7 July 2016

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under test conditions: No information available


Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
2.9
Temp.:
32 °C
pH:
7

Applicant's summary and conclusion

Conclusions:
The partition coefficient (Log Pow) of octan-3-one is 2.9 at 32°C at pH 7.
Executive summary:

The test item octan-3-one has a partition coefficient (Log Pow) of 2.9 at 32°C at pH 7 according to the guideline OECD 117, EU Method A.8 and OPPTS 830.7570, using the HPLC method under GLP.