Registration Dossier
Registration Dossier
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EC number: 209-667-4 | CAS number: 589-98-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- data is from peer reviewed journals and hasndbooks
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monographs on Fragrance Raw Materials: 3-Octanol
- Author:
- D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 17, Supplement, December 1979, Page 881
- Reference Type:
- review article or handbook
- Title:
- Toxicity Evaluation of 3-octanol
- Author:
- Edited by Eula Bingham and Barbara Cohrssen
- Year:
- 2 012
- Bibliographic source:
- Patty’s Toxicology, Sixth Edition, Volume 1, pg 10-11, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- To assess the irritation potential of 3-octanol in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Octan-3-ol
- EC Number:
- 209-667-4
- EC Name:
- Octan-3-ol
- Cas Number:
- 589-98-0
- Molecular formula:
- C8H18O
- IUPAC Name:
- octan-3-ol
- Test material form:
- liquid
- Details on test material:
- - Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles : C([C@@H](CC)O)CCCC
- Inchl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles Notation: C([C@@H](CC)O)CCCC
- InChl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 100% undiluted
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours
- Number of animals:
- no data available
- Details on study design:
- no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- Moderately irritating to skin
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- 3-octanol was irritating to rabbit skin after 24 hours exposure.
- Executive summary:
A skin irritation study was performed in rabbits to assess the irritation potential of 3-octanol. 3-octanol was applied undiluted to the intact and abraded skin of rabbits under occlusion. The rabbits were observed for signs of irritation till 24 hours. 3-octanol was irritating to rabbit skin after 24 hours exposure.
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