Registration Dossier
Registration Dossier
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EC number: 209-667-4 | CAS number: 589-98-0
Endpoint summary
Administrative data
Description of key information
Short-term toxicity to aquatic invertebrates:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the short term aquatic toxicity to invertebrates was estimated forcopper, 3-Octanol. The EC50 was estimated to be 184 mg/l when Daphnia magna was exposed with3-Octanol.
On the basis of the effect concentration the test chemical is considered non-toxic and can be classified in the category "Not classified" as per CLP classification.
Toxicity to aquatic algae and cynobacteria:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the short term toxicity to algae and cynobacteria was estimated forcopper, 3-Octanol. The EC50 was estimated to be 114 mg/l whenPseudokirchneriella subcapitatawas exposed with3-Octanol.
On the basis of the effect concentration the test chemical is considered non-toxic and can be classified in the category "Not classified" as per CLP classification.
Additional information
Short-term toxicity to aquatic invertebrates:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the short term aquatic toxicity to invertebrates was estimated forcopper, 3-Octanol. The EC50 was estimated to be 184 mg/l when Daphnia magna was exposed with3-Octanol.
On the basis of the effect concentration the test chemical is considered non-toxic and can be classified in the category "Not classified" as per CLP classification.
The above prediction was supported by experimental data summarized in Hazardous substance databank for 2-ETHYL-1-HEXANOL U.S National Library of Medicine 2013 and Water Research 38 (2004) 3693–3698 for the structurally similar read across substance 2 -Ethyl-1 -Hexanol (CAS 104 -76 -7).
2-ethylhexan-1-ol was used as a test material to evaluate its toxicity on Daphnia magna for 48 h . The test chemical was introduce in the concentration 100%,50%,25%,12.5% and 6.25% by volume) of solutions of 300 mg/L.The effect concentration (LC50) was observed to be 100 mg/l and the confidence interval is observed within (78-160 mg/l).
The above experimental study was supported by experimental result of another structurally similar read across substance octane-1 -ol (CAS: 111 -87 -5) summarized in Hazardous substance databank for 1-OCTANOL U.S National Library of Medicine 2013.
Octan-1-ol was used as a test material to evaluate toxicity on Daphnia magna in static condition for 42 h. The effect concentration (EC50) of Octan-1-ol on Daphnia magna after 24 h was observed to be 26mg/l.
Even though the above effect concentration is considered as toxic, but Octan-1-ol is readily degradable in aquatic environment . Hence, Octan-1-ol is considered to be non toxic to Daphnia magna.
On the basis of effect concentration of tarfet as well as read across substance and considering the property of readily biodegradibility of the test chemical
3-Octanol can be considered non- toxic to aquatic invertebrates and can be classified as " Not classified" as per CLP.
Toxicity to aquatic algae and cynobacteria:
In a prediction done by SSS (2018) using the OECD QSAR toolbox with log kow as the primary descriptor, the short term toxicity to algae and cynobacteria was estimated forcopper, 3-Octanol. The EC50 was estimated to be 114 mg/l whenPseudokirchneriella subcapitatawas exposed with3-Octanol.
On the basis of the effect concentration the test chemical is considered non-toxic and can be classified in the category "Not classified" as per CLP classification.
The above prediction was suppported by experimental study summarized in ECOTOX database, U. S. Environmental Protection Agency, 2018 for the structurally similar read across substance 2 Ethylhexanol (CAS: 104 -76 -7).
2-Ethylhexanol was used as a test material to evaluate its toxicity on Chlorella emersonii (Green Algae) strain STRAIN 211/8 H the effect concentration was observed to be 10-50 mg/l at 48 h.
The above effect concentration was considered to be toxic, but the test chemical 2-Ethylhexanol was readily biodegradable .Hence , 2-Ethylhexanol can be considered as “Not classified” for toxicity to algae and cynobacteria.
Exeperimental study of another structurally similar read across substance Hexan-1-ol (111 -27 -3) was used to support above result summarized in
ECOTOX database, U. S. Environmental Protection Agency, 2018.
Hexan-1-ol was used as a test material to evaluate its toxicity on Chlorococcales green algae for 24 hrs in static condition . The effect concentration (EC50) at which population of algae was effect was observed to be 230 mg/l.
On the basis of effect concentration of tarfet as well as read across substance and considering the property of readily biodegradibility of the test chemical
3-Octanol can be considered non- toxic to aquatic invertebrates and can be classified as " Not classified" as per CLP
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