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Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: 3-Octanol
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology,Volume 17, Supplement, December 1979, Page 881
Reference Type:
review article or handbook
Title:
Toxicity Evaluation of 3-octanol
Author:
Edited by Eula Bingham and Barbara Cohrssen
Year:
2012
Bibliographic source:
Patty’s Toxicology, Sixth Edition, Volume 1, pg 10-11, 2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Maximization test
Principles of method if other than guideline:
To evaluate skin sensitization potential of 3-octanol on 29 human volunteers
GLP compliance:
not specified
Type of study:
other: Maximization test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Octan-3-ol
EC Number:
209-667-4
EC Name:
Octan-3-ol
Cas Number:
589-98-0
Molecular formula:
C8H18O
IUPAC Name:
octan-3-ol
Test material form:
liquid
Details on test material:
- Name of test material: 3-Octanol
- IUPAC name: Octan-3-ol
- Molecular formula: C8H18O
- Molecular weight: 130.229 g/mole
- Smiles : C([C@@H](CC)O)CCCC
- Inchl: 1S/C8H18O/c1-3-5-6-7-8(9)4-2/h8-9H,3-7H2,1-2H3
- Substance type: Organic
- Physical state: Colorless Liquid
Specific details on test material used for the study:
Name of the test chemical: 3-Octanol
Molecular Formula: C8H18O
Molecular Weight: 130.229 g/mole
Substance type: organic
Physical state: Liquid

In vivo test system

Test animals

Species:
other: humans
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data available

Study design: in vivo (non-LLNA)

Induction
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
12% in petrolatum
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
epicutaneous, occlusive
Vehicle:
petrolatum
Concentration / amount:
12% in petrolatum
Adequacy of challenge:
not specified
No. of animals per dose:
29 human volunteers
Details on study design:
no data available
Challenge controls:
no data available

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
12% in petrolatum
No. with + reactions:
0
Total no. in group:
29
Clinical observations:
no dermal reactions observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: not sensitizing
Conclusions:
3-octanol 12% in petrolatum when tested for skin sensitization on 29 human volunteers showed no skin reaction. Hence, 3-octanol can be considered as not skin sensitizer for human skin.
Executive summary:

3-octanol was used as test material to evaluate skin sensitization potential by human maximization test.

3-octanol 12% in petrolatum was applied on the skin of 29 human volunteers. No skin reactions were observed. Hence, 3-octanol can be considered as not skin sensitizer for human skin.