Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: prediction
Title:
QSAR prediction of methyl-guanidyl-thiazole dihydrochloride
Author:
Gedeon Richter Plc.
Year:
2016
Bibliographic source:
QSAR Toolbox

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}methanimidamide dihydrochloride
EC Number:
618-106-6
Cas Number:
88046-01-9
Molecular formula:
C6H12Cl2N6S2
IUPAC Name:
{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}methanimidamide dihydrochloride

Test animals

Species:
rat

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 050 mg/kg bw
Remarks on result:
other: prediction

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria