Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
repeated dose toxicity: oral, other
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification

Data source

Reference
Reference Type:
other: prediction
Title:
QSAR prediction of methyl-guanidyl-thiazole dihydrochloride
Author:
Gedeon Richter Plc.
Year:
2016
Bibliographic source:
QSAR Toolbox

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
QSAR

Test material

Constituent 1
Chemical structure
Reference substance name:
{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}methanimidamide dihydrochloride
EC Number:
618-106-6
Cas Number:
88046-01-9
Molecular formula:
C6H12Cl2N6S2
IUPAC Name:
{[(2-carbamimidamido-1,3-thiazol-4-yl)methyl]sulfanyl}methanimidamide dihydrochloride

Results and discussion

Effect levels

Dose descriptor:
NOEL
Effect level:
206 mg/kg bw/day (nominal)
Remarks on result:
other: prediction

Target system / organ toxicity

Critical effects observed:
not specified
Organ:
not specified

Applicant's summary and conclusion