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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 October 2015 - 01 April 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
- Batch n°: I15FB2768
- Analytical purity (acid titration): 100% (base titration)
- Expiration date: 1 July 2017
- Storage condition: at room temperature
Key result
Temp.:
20 °C
Vapour pressure:
< 0 Pa
Key result
Temp.:
25 °C
Vapour pressure:
< 0 Pa

Reference substances

Validation of the method is performed at least once every year (WIL project 512159). Each reference substance was measured in duplicate by TGA using a temperature program that was specific for the substance. Plots of log vTobtained at elevated temperatures and 1/T were inter- or extrapolated to determine the log vTvalues at 20°C (log vT,20). The log vT,20values were plotted against the logarithm of the vapour pressure at 20°C in Pascal units (log PT,20). Linear regression analysis using the least squares method yielded an equation of log PT,20= 1.14 log vT,20+ 4.55. The coefficient of correlation (r) was > 0.99. The constants c and d specific for the experimental arrangement were 1.14 and 4.55, respectively.

Results

Isothermal TGA analysis: from the plot of the log PTof the test item as a function of the reciprocal temperature the equation of the curve could be derived: log PT= -7239 x 1/T + 16.08 (r = 0.991, n = 9). The calculated results for the vapour pressure of the test item at 20°C and 25°C is:

 Temperature (°C)  log PT  PT (Pa)  PT (mm Hg)
 20  -8.61  2.4 E-9  1.8 E-11
 25  -8.20  6.3 E-9  4.8 E-11

The calculated results were outside of the validated range of the method. Therefore, the vapour pressure of the test item is reported as less than the vapour pressure of benzo(ghi)perylene, which is the reference substance with the lowest vapour pressure used during the method validation.

 

 

 

Conclusions:
The isothermal TGA effusion method was applied for the determination of the vapour pressure of JNJ-1806792-AAA (T001325).
The vapour pressure of the test item was determined to be < 1.3 E-8 Pa (or < 1.0 E-10 mmHg) at 20°C (293K) and < 1.9 E-8 Pa (or < 1.4 E-10 mmHg) at 25°C (298K).

Description of key information

The vapour pressure of T001325 was assessed using the isothermal TGA effusion method, following the guidelines OECD 104, EU method A.4 and EPA OPPTS 830.7950 (K1, Reingruber, 2017) and was determined to be < 1.3 E-8 Pa at 20°C and < 1.9 E-8 Pa at 25°C.

Key value for chemical safety assessment

Additional information