Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Melting point / freezing point

Currently viewing:

Administrative data

Link to relevant study record(s)

melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 October 2015 - 01 April 2016
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
according to guideline
OECD Guideline 102 (Melting point / Melting Range)
according to guideline
EU Method A.1 (Melting / Freezing Temperature)
according to guideline
EPA OPPTS 830.7200 (Melting Point / Melting Range)
GLP compliance:
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
- Batch n°: I15FB2768
- Analytical purity (acid titration): 100% (base titration)
- Expiration date: 1 July 2017
- Storage condition: at room temperature
Key result
Melting / freezing pt.:
193 °C
Atm. press.:
1 013.25 hPa
Decomp. temp.:
> 275 °C
Remarks on result:
other: A black molten residue remained after the preliminary and main test (first cycle), indicating reaction and/or decomposition.

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly from 300°C. At 355°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: brown). The change of the colour indicated reaction and/or decomposition of the test item.

Main tests

In order to determine the melting more precisely, a DSC curve was obtained with a heating rate of 20°C/min and showed an endothermic peak between 175°C and 225°C. The extrapolated onset temperature of the peak was 193.10°C. The effect was most likely obtained due to melting. An exothermic peak was observed between 275°C and 350°C due to reaction and/or decomposition of the test item. After the experiment, a black molten residue remained. To investigate the melting peak between 175°C and 225°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 192.95°C. The melting temperature of T001325 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 193.0°C (466.2K).

The melting temperature of JNJ-1806792-AAA (T001325) was determined at 193.0°C (466.2 K) by using DSC.

Description of key information

A GLP study was performed according to OECD guideline 102, EU Method A.1 and EPA OPPTS 830.7200 without deviations (Reingruber, 2017). The melting point of T001325 was determined to be 193.0°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
193 °C

Additional information