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EC number: 616-145-3 | CAS number: 74852-61-2
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 October 2015 - 01 April 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Batch n°: I15FB2768
- Analytical purity (acid titration): 100% (base titration)
- Expiration date: 1 July 2017
- Storage condition: at room temperature - Key result
- Melting / freezing pt.:
- 193 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Decomp. temp.:
- > 275 °C
- Remarks on result:
- other: A black molten residue remained after the preliminary and main test (first cycle), indicating reaction and/or decomposition.
- Conclusions:
- The melting temperature of JNJ-1806792-AAA (T001325) was determined at 193.0°C (466.2 K) by using DSC.
Reference
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly from 300°C. At 355°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: brown). The change of the colour indicated reaction and/or decomposition of the test item.
Main tests
In order to determine the melting more precisely, a DSC curve was obtained with a heating rate of 20°C/min and showed an endothermic peak between 175°C and 225°C. The extrapolated onset temperature of the peak was 193.10°C. The effect was most likely obtained due to melting. An exothermic peak was observed between 275°C and 350°C due to reaction and/or decomposition of the test item. After the experiment, a black molten residue remained. To investigate the melting peak between 175°C and 225°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 192.95°C. The melting temperature of T001325 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 193.0°C (466.2K).
Description of key information
A GLP study was performed according to OECD guideline 102, EU Method A.1 and EPA OPPTS 830.7200 without deviations (Reingruber, 2017). The melting point of T001325 was determined to be 193.0°C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 193 °C
Additional information
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