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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 October 2015 - 01 April 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Specific details on test material used for the study:
- Batch n°: I15FB2768
- Analytical purity (acid titration): 100% (base titration)
- Expiration date: 1 July 2017
- Storage condition: at room temperature
Key result
Melting / freezing pt.:
193 °C
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Decomp. temp.:
> 275 °C
Remarks on result:
other: A black molten residue remained after the preliminary and main test (first cycle), indicating reaction and/or decomposition.

Preliminary test

From the TGA curve it could be derived that the weight of the sample decreased significantly from 300°C. At 355°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: brown). The change of the colour indicated reaction and/or decomposition of the test item.

Main tests

In order to determine the melting more precisely, a DSC curve was obtained with a heating rate of 20°C/min and showed an endothermic peak between 175°C and 225°C. The extrapolated onset temperature of the peak was 193.10°C. The effect was most likely obtained due to melting. An exothermic peak was observed between 275°C and 350°C due to reaction and/or decomposition of the test item. After the experiment, a black molten residue remained. To investigate the melting peak between 175°C and 225°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 192.95°C. The melting temperature of T001325 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 193.0°C (466.2K).

Conclusions:
The melting temperature of JNJ-1806792-AAA (T001325) was determined at 193.0°C (466.2 K) by using DSC.

Description of key information

A GLP study was performed according to OECD guideline 102, EU Method A.1 and EPA OPPTS 830.7200 without deviations (Reingruber, 2017). The melting point of T001325 was determined to be 193.0°C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
193 °C

Additional information