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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal.

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs - FENCHONE
Author:
D.L.J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology 1979, Pages 380–382

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study of Fenchone (CAS No: 1195-79-5) was conducted on human subjects to determine the degree of skin irritancy caused by the chemical under occlusive condition.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3-dimethyl-8,9-dinorbornan-2-one
EC Number:
214-804-6
EC Name:
3,3-dimethyl-8,9-dinorbornan-2-one
Cas Number:
1195-79-5
Molecular formula:
C10H16O
IUPAC Name:
1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
liquid
Details on test material:
- Name of test material : 3, 3-Dimethyl-8, 9-dinorbornan-2-one
- Common name : 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Molecular formula : C10H16O
- Molecular weight : 152.2354 g/mol
- Smiles notation : C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl : 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: 3,3-Dimethyl-8,9-dinorbornan-2-one
- Common name: 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one / Fenchone
- Molecular formula: C10H16O
- Molecular weight: 152.2354 g/mol
- Smiles notation: C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl: 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
other: Human
Strain:
other: Not applicable
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
4%
Duration of treatment / exposure:
48 hours
Observation period:
48 hours
Number of animals:
No Data Available
Details on study design:
No Data Available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No known signs of skin irritation were observed.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material Fenchone (CAS No: 1195-79-5) was considered to be not irritating to the skin of human subjects.
Executive summary:

Skin irritation study of Fenchone (CAS No: 1195-79-5) was conducted on human subjects to determine the degree of skin irritancy caused by the chemical.

 

Each subject was treated with 4% of Fenchone (CAS No: 1195-79-5) in petrolatum dermally for 48 hours under a closed path patch.

 

Since no known signs of irritation was observed, the chemicalFenchone (CAS No: 1195-79-5)was considered to be not irritating to theskin of human subjects.