Registration Dossier
Registration Dossier
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EC number: 214-804-6 | CAS number: 1195-79-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from Danish QSAR
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 1195-79-5
- Author:
- Danish (Q)SAR Database
- Year:
- 2 018
- Bibliographic source:
- Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done by using Danish QSAR
- GLP compliance:
- not specified
- Type of study:
- other: Allergic Contact Dermatitis in Guinea Pig and Human
- Justification for non-LLNA method:
- Not specified.
Test material
- Reference substance name:
- 3,3-dimethyl-8,9-dinorbornan-2-one
- EC Number:
- 214-804-6
- EC Name:
- 3,3-dimethyl-8,9-dinorbornan-2-one
- Cas Number:
- 1195-79-5
- Molecular formula:
- C10H16O
- IUPAC Name:
- 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 3, 3-Dimethyl-8, 9-dinorbornan-2-one
- Common name : 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Molecular formula : C10H16O
- Molecular weight : 152.2354 g/mol
- Smiles notation : C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl : 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 3,3-Dimethyl-8,9-dinorbornan-2-one
- Common name: 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one / Fenchone
- Molecular formula: C10H16O
- Molecular weight: 152.2354 g/mol
- Smiles notation: C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl: 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid
In vivo test system
Test animals
- Species:
- other: Guinea Pig and Human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: No data available.
Challenge
- Route:
- other: No data available.
- No. of animals per dose:
- No data available.
- Details on study design:
- No data available.
- Challenge controls:
- No data available.
- Positive control substance(s):
- not specified
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Clinical observations:
- No skin sensitization effect were observed.
- Remarks on result:
- no indication of skin sensitisation
Any other information on results incl. tables
Domain applicability: In domain
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- According to Danish QSAR database , the skin sensitization effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) . Based on estimation, no skin sensitization reactions were observed in guinea Pig and Human. Therefore, 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was considered to be not sensitizing.
- Executive summary:
According to Danish QSAR database , the skin sensitization effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) . Based on estimation, no skin sensitization reactions were observed in guinea Pig and Human. Therefore, 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was considered to be not sensitizing.
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