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Diss Factsheets
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EC number: 203-775-5 | CAS number: 110-52-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviwed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Structure activity relationships in skin sensitization using the murine local lymph node assay
- Author:
- J. Ashby et. al.
- Year:
- 1 995
- Bibliographic source:
- Toxicology 103 (1995)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- The skin sensitizing potential of the test chemical was assessed by using the Mouse Local Lymph node Assay.
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 1-bromohexane
- EC Number:
- 203-850-2
- EC Name:
- 1-bromohexane
- Cas Number:
- 111-25-1
- Molecular formula:
- C6H13Br
- IUPAC Name:
- 1-Bromohexane
- Test material form:
- liquid
- Details on test material:
- IUPAC name: 1-bromohexane
Mol. formula: C6H13Br
Molecular Weight: 165.073 gm/mol
Smiles: C(CCC)CCBr
InChI: 1S/C6H13Br/c1-2-3-4-5-6-7/h2-6H2,1H3
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (LLNA)
- Vehicle:
- other: AOO (Acetone/olive oil, 80/20 v/v)
- Concentration:
- 5%, 10% and 25%
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Positive control substance(s):
- not specified
- Statistics:
- No data available
Results and discussion
- Positive control results:
- No data available
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- other: T/C ratio
- Value:
- 1.2
- Test group / Remarks:
- Concentration 5%
- Remarks on result:
- other: Not sensitizing
- Parameter:
- other: T/C ratio
- Value:
- 1.4
- Test group / Remarks:
- Concentration 10%
- Remarks on result:
- other: Not sensitizing
- Parameter:
- other: T/C ratio
- Value:
- 2.1
- Test group / Remarks:
- Concentration 25%
- Remarks on result:
- other: Not sensitizing
- Cellular proliferation data / Observations:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not sensitizing
- Conclusions:
- The values for Stimulation Indices at various test concentrations were 1.2, 1.4 and 2.1 which are below 3, hence EC3 value couldnot be calculated. Therefore, the given test chemical was considered to be not sensitizing to skin of mice.
- Executive summary:
The dermal sensitization potential of the given test chemical was evaluated in a mouse local lymphnode assay (LLNA). Groups mice were exposed topically on the dorsum of both ears to 5%, 10% and 25% of the test material or to an equal volume of relevant vehicle only. Treatment was performed daily for 3 consecutive days. Five days after the initiation of exposure, all mice were injected intravenously with [H3] thymidine and activity measured as a function of isotope incorporation in draining auricular lymph nodes. The approach to estimation of the relative skin sensitization potential was based on the mathematical estimation of the concentration of chemical necessary to obtain a threshold positive response (SI = 3); this is termed as the EC3 value. A substance was classified as a skin sensitizer if it induced a threefold or greater increase in local lymph node proliferative activity at one or more test concentrations when compared with concurrent vehicle-treated controls (SI≥3). The values for Stimulation Indices at various test concentrations were 1.2, 1.4 and 2.1 which are below 3, hence EC3 value couldnot be calculated. Therefore, the given test chemical was considered to be not sensitizing to skin of mice.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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