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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.231
Temp.:
25 °C
pH:
7.4

Table:

Test substance

K

Log k

Log Pow

Mean of Log Pow ±

 S.D.

Rt1

2.087

1.220

0.086

3.232

3.231± 0.002

Rt2

2.084

1.217

0.085

3.230

 

Conclusions:
The partition coefficient (n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.231± 0.002 dimensionless at 25°C.
Executive summary:

The partition Coefficient n-octanol/water of test chmeical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.3 to 6.5.The Log Pow value was determined to be 3.231± 0.002 dimensionless at 25°C.

Description of key information

The partition coefficient (n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.231± 0.002 dimensionless at 25°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.231
at the temperature of:
25 °C

Additional information

The partition Coefficient n-octanol/water of test chmeical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared. The reference substances were having Pow value ranging from 0.3 to 6.5.The Log Pow value was determined to be 3.231± 0.002 dimensionless at 25°C.

Based on the available data from authoritative database, octanol water partition coefficient of the test substance was determined according to OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method). The log Pow value of the substance was determined to be in the range from 2.7-2.75.