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Registration Dossier
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EC number: 231-836-6 | CAS number: 7758-19-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2nd January 1985 to 22nd January 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- No data on GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA guidelines 8/22/78 (40 CFR Part 163)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium chlorite
- EC Number:
- 231-836-6
- EC Name:
- Sodium chlorite
- Cas Number:
- 7758-19-2
- Molecular formula:
- ClHO2.Na
- IUPAC Name:
- sodium chlorite
- Test material form:
- liquid
- Details on test material:
- Test material: sodium chlorite 31% aqueous
Pale yellow liquid in white plastic bottle
Sample: T-1014 (32676)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Adult New Zeland albino rabbits, both sexes weights 2 kg.
-rabbit food and water ad libitum
-12 hour night-day lighting cycle
-relative humidity 40-50%
-temperature of animal room 20-25ºC
-indirect bedding of absorbent liners over pine shavings-stainless steel wire cages of USDA specifications-animal quarantine and acclimitization prior to dosing
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- The animals were clipped dorso-laterally from the pectoral to the pelvic areas. The test substance was moistened with water to form a paste and applied to the skin to cover no less than 10% of the body surface area.The treated skin was covered for 24 hours with a gauze dressing and a plastic over-wrap which were held to the skin under a rubberized sleeve.
- Duration of exposure:
- After 24 hours of semi-occlusive application, the animals were observed twice daily for signs of illness.
- Doses:
- 1.67 ml (2.0 g of liquid) per kilogram bw
- No. of animals per sex per dose:
- 10 animals per dose, both sexes
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths found
- Gross pathology:
- Observations in all rabbits were normal except:-in 1 male rabbit: clear ascites in abdominal cavity. However, it is not believed to be due to the administration of the test material.-in 1 female rabbit: scattered petecchiae throughout all lobes of lung
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified according to CLP Regulation.
- Conclusions:
- The result was as follows:Dermal LD50 >2000 mg//kg bw (31% aqueous solution)
- Executive summary:
The purpose of the study is to determine the topical (dermal) dose that is lethal to 50% of adult rabbits
The test was performed according to method EPA guideline 8/22/78 (40 CFR, Part 163).
10 adult New Zealand albino rabbits were used (both sexes, weights 2 kg).
The dose rate was 1.67 ml (2.0 g of liquid) bw.
After 24 hours of semi-occlusive application, the animals were observed twice daily for signs of illness.
The result was as follows:
Dermal LD50 >2000 mg//kg bw (31% aqueous solution)
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