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EC number: 231-836-6 | CAS number: 7758-19-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- In vivo (non LLNA). The study was conducted before the entry into force of REACH Regulation.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Version / remarks:
- and EU Method B.6 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- The test was conducted in 2002 before REACH Regulation (EC) 1907/2006 entered into force.
Test material
- Reference substance name:
- Sodium chlorite
- EC Number:
- 231-836-6
- EC Name:
- Sodium chlorite
- Cas Number:
- 7758-19-2
- Molecular formula:
- ClHO2.Na
- IUPAC Name:
- sodium chlorite
- Test material form:
- liquid
- Details on test material:
- Test material: Sodium chlorite (31% solution)
Lot/Batch number: 6624 (Atofina)
Description: Light yellow liquid
Purity: 31.12 %
Preparation of test substance for application:
a) for induction: In 0.9% NaCl
b) for challenge: In 0.9% NaCl
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- Source:Charles River Laboratories, Saint-Aubin-les-Elbeuf, France.
Sex:Male and female (nulliparous and non-pregnant)
Age/weight at study initiation:Age: 1 – 3 months old
Mean body weight males: 380 ± 31 g; females: 355 ± 13 g.
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- other: 0.9 % NaCl
- Concentration / amount:
- Concentrations used for induction:0.031 % sodium chlorite (i.e. a 0.1 % solution of a 31 % solution of sodium chlorite)
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: 0.9 % NaCl
- Concentration / amount:
- Concentrations used for challenge:0.31 % sodium chlorite (i.e. a 1 % solution of a 31 % solution of sodium chlorite)
- No. of animals per dose:
- 10 animals/sex/group
- Details on study design:
- INDUCTION SCHEDULE:Intradermal route:Day 1: six injections were made into the dermis of a 4 cm x 2 cm clipped interscapular area using a needle (0.50 x 16 mm diameter). Three injections of 0.1 mL were made into each side of this interscapsular region.Cutaneous route:As the test item was shown to be irritant during the preliminary test, a topical application with sodium lauryl sulphate was not necessary on day 7.Day 8: a pad of filter paper (~8 cm2) was fully loaded with the test item at the concentration of 5% (w/w) (i.e. 1.55% sodium chlorite) and was then applied to the interscapular region of the animal of the treated group. The pad was held in place for 48 h.
CHALLENGE SCHEDULE
On day 22, the animals received an application of the test item and vehicle. The filter paper of a chamber (Finn Chamber®) was fully loaded with the test item at the concentration of 1% (w/w) (i.e. 0.31% sodium chlorite) and was then applied to the clipped area of the skin of the posterior right flank. The vehicle was applied to the posterior left flank. The chambers were held in contact with the skin for 24 h by means of an adhesive allergenic waterproof plaster. - Challenge controls:
- 5 animals/sex were used as control animals and were treated with water.
- Positive control substance(s):
- yes
- Remarks:
- Mercaptobenzothiazole (as a separate study)
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 1 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No cutaneous reactions were observed.
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 1 %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No cutaneous reactions were observed.
Any other information on results incl. tables
Table A6_1_5-1. Detailed information including induction/challenge/scoring schedule for skin sensitisation test Guinea pig maximisation test (GPMT) |
|||||||
Inductions |
GPMT |
Observations/Remarks |
|
||||
day of treatment |
application |
|
|||||
Induction A |
0 |
intradermal |
|
||||
Induction B |
0 |
topical |
|
||||
challenge |
22 |
topical |
|
||||
scoring 1 |
23 |
No reactions were observed |
|
||||
scoring 2 |
24 |
No reactions were observed |
|
||||
Table A6_1_5-2. Result of skin sensitisation test |
|||||||
Number of animals with signs of allergic reactions / |
|||||||
Negative control |
Test group |
Positive control |
|||||
scored after 24h |
0/10 |
0/10 |
10/10 |
||||
scored after 48h |
0/10 |
0/10 |
10/10 |
||||
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- According to CLP criteria.
- Conclusions:
- No delayed contact hypersensitivity in guinea pigs was observed.
- Executive summary:
The aim of the study was to determine the skin sensitisation in guinea pig due to the test material.
The test procedure was conducted according to OECD Guideline 406 (Skin Sensitisation) under GLP conditions.
Result: no delayed contact hypersensitivity in guinea pigs was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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