Geranyl propionate

Endpoint summary

Description of key information

Short term toxicity to aquatic invertebrates:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8). Based on the immobility of test organism the EC50 value was estimated to be 2.17 mg/l when (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate exposed to Daphnia magna for 48hrs. Based on the EC50 value, chemical was consider as toxic and classified as aquatic chronic 2. But as the chemical was readily biodegradable in water so that it is concluded as nontoxic and not classified as per the CLP classification criteria.

Short term toxicity to aquatic algae:

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for Target substance (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate (105-90-8). EC50 value was estimated to be 1.92 mg/l for Species Pseudokirchneriella subcapitata for 72 hrs duration when exposed to (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate (Geranyl propionate). Based on the EC50 value, it can be concluded that the chemical was toxic and can be consider to be classified in aquatic chronic 2 category, but the chemical was readily biodegradable in water. Based on this ready biodegradability of chemical it can be concluded that the substance (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoateis considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

Additional information

Summarized result of toxicity of (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8) on the growth and other activity of aquatic invertebrates, algae and cyanobacteria by considering the data for target as well as RA chemical which was selected on the basis of log Kow as the primary descriptor and structural similarity are as follows:  

Short term toxicity to aquatic invertebrates:

Various predicted data for the target compound (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8) and supporting weight of evidence studies for its closest read across substance with log Kow as the primary descriptor were reviewed for the toxicity on the invertebrates end point which are summarized as below: 

In a prediction done by SSS (2017), using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, toxicity on Daphnia magna was predicted for (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8). Based on the immobility of test organism the EC50 value was estimated to be 2.17 mg/l when (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate exposed to Daphnia magna for 48hrs. Based on the EC50 value, chemical was consider as toxic and classified as aquatic chronic 2. But as the chemical was readily biodegradable in water so that it is concluded as nontoxic and not classified as per the CLP classification criteria.

Similarly in a supporting weight of evidence study from authoritative database HSDB, ECOTOX 2017, for read across chemical (138-22-7), Determination of short term toxicity of butyl 2-hydroxypropanoate on the growth of daphnia magna for 48 hrs. Test was performed in the static condition. After the exposure of chemical, effect concentration was measured at which 50% growth inhibited. Based on the immobilization of daphnia magna due to the exposure of chemical butyl 2-hydroxypropanoate, the EC50 was 320 mg/l.(95% confidence interval of 320000-399000 ug. Thus it can be concluded that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

In the third weight of evidence study for the RA chemical (97-64-3) HSDB, ECOTOX toxicity was studied. Determination of short term toxicity of chemical ethyl (2R)-2-hydroxypropanoate on the growth of freshwater daphnia magna for 48hrs. Test was performed in the static condition. After the exposure of chemical, effect concentration was measured at which 50% growth inhibited. Based on the immobilization of daphnia magna due to the exposure of chemical ethyl (2R)-2-hydroxypropanoate, the EC50 was 560 mg/l. with 95% CI of 560000-763000 ug/L. Thus it can be concluded that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

Similarly in the fourth weight of evidence study for another RA chemical (6382-06-5), from ECOTOX database, Determination of short term toxicity of chemical pentyl 2-hydroxypropanoate on the growth of daphnia magna for 48 hrs. Test was performed in the static condition. After the exposure of chemical, effect concentration was measured at which 50% growth inhibited. Based on the immobilization of daphnia magna due to the exposure of chemical 2-hydroxypropanoate, the EC50 was 238 mg/l with 95% confidence interval of (206000-274000 ug/l). Thus it can be concluded that the chemical was nontoxic and can be consider to be not classified as toxic as per the CLP classification criteria.

 

On the basis of above results for target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8) (from OECD QSAR toolbox version 3.4, 2017) and for its read across substance from HSDB, ECOTOX, it can be concluded that the test substance (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate (Geranyl propionate)is not toxic and can be consider to be not classified as toxic as per the CLP classification criteria.

Short term toxicity to aquatic algae:

Various predicted data for the target compound (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8) and supporting weight of evidence studies for its closest read across substance with log Kow as the primary descriptor were reviewed for the toxicity on the algae end point which are summarized as below: 

 

In a prediction done by SSS (2017), using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the five closest read across substances, the toxicity on Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum) was predicted for Target substance (2E)-3,7- dimethylocta -2,6-dien-1-yl propanoate (105-90-8). EC50 value was estimated to be 1.92 mg/l for Species Pseudokirchneriella subcapitata for 72 hrs duration when exposed to (2E)-3,7- dimethylocta-2,6-dien-1-yl propanoate (Geranyl propionate). Based on the EC50 value, it can be concluded that the chemical was toxic and can be consider to be classified in aquatic chronic 2 category, but the chemical was readily biodegradable in water. Based on this ready biodegradability of chemical it can be concluded that the substance (2E)-3,7-dimethylocta- 2,6-dien-1-yl propanoateis considered as nontoxic to aquatic environment as per the criteria mentioned in CLP regulation. 

 

Similarly in a supporting weight of evidence study from ABITEC report 2016 for read across chemical 3,7-dimethylocta-2,6-dien-1-yl butyrate, Geranyl butyrate (106-29-6) toxicity experiment was conducted for evaluating the effect of read across substance. Freshwater algal growth inhibition test was carried out on Desmodesmus subspicatus with the substance 3,7-dimethylocta-2,6-dien-1-yl butyrate, Geranyl butyrate according to OECD Guideline 201. The test substance was dissolved in acetone and tested at the concentrations 0, 0, 33, 50, 75, 113, 170 mg/L. Effects on the growth rate of the organism were studied. The median effective concentration (ErC50) for the test substance, 3,7-dimethylocta-2,6-dien-1-yl butyrate in Desmodesmus subspicatus was determined to be 100.3 mg/L. This value indicates that the substance is likely to be non-hazardous to aquatic algae and cannot be classified as toxic as per the CLP criteria.

 

In the third weight of evidence study for the RA chemical (97-64-3) ECOTOX toxicity was studied. Determination of short term toxicity of chemical ethyl (2R)-2-hydroxypropanoate on the growth of aquatic green algae. Test was performed in the static system for 72-96 hrs. 10000 cells /ml total biomass concentration of algal cells was taken in the study. After the exposure of chemical, effect concentration was measured on the basis of inhibition of biomass rate. Based on the inhibition of biomass rate of green algae (Pseudokirchneriella Subcapitata) due to the exposure of chemical ethyl (2R)-2-hydroxypropanoate, the EC50 was 2300 mg/l. Based on the EC50, it was concluded that the chemical was nontoxic and can be consider to be no classified as toxic as per the CLP classification criteria.

 

On the basis of above results for for toxicity of target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate; Geranyl propionate (105-90-8) (from OECD QSAR toolbox version 3.4, 2017) and for its read across substance from ABITEC report, secondary sources and authoritative database, on the invertebrates and algae it can be concluded that the test substance (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate (Geranyl propionate) is not toxic and can be consider to be not classified as toxic as per the CLP classification criteria.