Registration Dossier
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EC number: 203-344-1 | CAS number: 105-90-8
Endpoint summary
Administrative data
Description of key information
Hydrolysis
HYDROWIN v2.00 program of Estimation Programs Interface (EPI Suite, 2017) prediction model was used to predict the hydrolysis half-life of test compound (2E)-3,7 -dimethylocta-2,6 -dien-1 -yl propanoate (CAS No. 105 -90 -8). The estimated half-life of (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate was estimated to be 274.146 days and 27.415 days at pH 7 and 8 (at 25 deg C) respectively, indicating that it is not hydrolysable.
Additional information
Hydrolysis
Predicted data for the target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate (CAS No. 105-90-8) and supporting weight of evidence study from authoritative database for its read across substance were reviewed for the hydrolysis end point which are summarized as below:
In aprediction using the HYDROWIN v2.00 program of Estimation Programs Interface (EPI Suite, 2017) prediction model, the hydrolysis half-life of test compound (2E)-3,7 -dimethylocta-2,6 -dien-1 -yl propanoate (CAS No. 105 -90 -8) was estimated. The estimated half-life of (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate was estimated to be 274.146 days and 27.415 days at pH 7 and 8 (at 25 deg C) respectively, indicating that it is not hydrolysable.
In a supporting weight of evidence study from authoritative database (HSDB, 2017) for the read across chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate (CAS no. 105-87-3), the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the read across chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate. The second order hydrolysis rate constant of (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate was determined to be 0.35L/mol-sec with a corresponding half-lives of 231 and 23 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl acetate is not hydrolysable.
On the basis of the above results for target chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate(fromEPI Suite, 2017) and for its read across substance (from authoritative database HSDB, 2017), it can be concluded that the test chemical (2E)-3,7-dimethylocta-2,6-dien-1-yl propanoate is not hydrolysable.
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