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EC number: 239-343-8 | CAS number: 15306-17-9
Endpoint summary
Administrative data
Description of key information
NOAEL Tris(ethyl acetoacetato-O1',O3)aluminium(repeated oral toxicity rat 28 days) = 798 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 798 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Study conducted according to internationally accepted testing guidelines.
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
For the assessment of oral repeated dose toxicity of Tris(ethyl acetoacetato-O1',O3)aluminium a read-across approach was used based on the information available for similar substance 1 and for similar substance 2 (see read-across justification in section 13 of this IUCLID dossier).
NOEL similar substance 1 (repeated oral toxicity rat 28 days) = 1000 mg/kg bw /day and recalculated for Tris(ethyl acetoacetato-O1',O3)aluminium is 1062.5 mg/kg bw/day
NOAEL similar substance 2 (repeated oral toxicity rat 28 days) = 52 mg/kg bw/day and recalculated for Tris(ethyl acetoacetato-O1',O3)aluminium is 798 mg/kg bw/day.
Based on precautionary principle the lowest value of NOAEL, i.e. NOAEL (repeated oral toxicity rat 28 days) = 798 mg/kg bw/day, was chosen to assess the oral repeated dose toxicity of Tris(ethyl acetoacetato-O1',O3)aluminium.
Justification for classification or non-classification
Tris(ethyl acetoacetato-O1',O3)aluminium is not classified for repeated dose toxicity according to the CLP Regulation (EC.n.1272/2008). For justification see the results of available studies.
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