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EC number: 239-343-8
CAS number: 15306-17-9
The substance was tested for acute
oral toxicity according to EC Commission Directive 96/54/EC, Part5.1
tris "Acute Toxicity-Oral,Acute Toxic Class Method" and according to
OECD No.423, "Acute Oral Toxicity-Acute Toxic Class Method“.
The test item was administered by
oral gavage to three Wistar rats of each sex at 2000 mg/kg bodyweight.
Animals were subjected to daily observations and weekly determination of
body weight. Macroscopic examination was performed on the day of death
or after terminal sacrifice (day15).
One male was found dead on day 6. No
further mortality occurred. Hunched posture was noted in all males on
day 1 and hunched posture, lethargy, piloerection, ptosis and/or
chromodacryorrhoea were noted among the females during the study period.
Bodyweight loss and reduced body weight gain was noted among the animals
during the first week post treatment. All animals regained weight during
the second week. Macroscopic postmortem examination of the male found
dead on day 6 revealed abnormalities of the liver (right lateral lobe,
papillary process, right median lobe many grey/white foci). No
abnormalities were found at macroscopic examination of the surviving
The oral LD50 value of test item in
Wistar rats was established to exceed 2000 mg/kg body weight.
Based on these results and according
to the CLP Regulation (EC n.1272/2008) no classification regarding acute
oral toxicity is required for Tris(ethyl acetoacetato-O1',O3)aluminium.
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