Registration Dossier
Registration Dossier
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EC number: 212-686-0 | CAS number: 846-48-0
Endpoint summary
Administrative data
Description of key information
Skin irritation (Rat, GLP): non-irritant
[Bayer Schering Pharma AG, Report No. A49585, 2010-06-17]
Eye irritation (Rabbit, GLP): non-irritant
[Bayer Schering Pharma AG, Report No. A49728, 2010-06-16]
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The single dermal administration of boldenone (ZK 5320) to male and female rats in the doses of 2000 mg/kg was tolerated without any local skin irritations. (Bayer Schering Pharma AG, Report No. A49585, 2010-06-17)
The single administration of boldenone (ZK 5320) to the right eye of male and female rabbits results in slight to severe transient irritation on the rabbit conjunctiva and slight to moderate hyperemia on the iris on day 1 and day 2 which decreased from day 3 onwards and were fully reversible on day 8 after administration. (Bayer Schering Pharma AG, Report No. A49728, 2010-06-16)
Justification for classification or non-classification
Boldenone (ZK 5320) was tested in one skin and one eye irritation test and did not show significant irritation potential.
Classification according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP) is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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