Tetrachloro-p-benzoquinone

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1988

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Test procedure according to national standard but without GLP. Exposure time only 24 hours; results taken from literature

Data source

Reference

Reference Type:

review article or handbook

Title:

BUA Report 85, Ref. Rhône-Poulenc, 1991b

Author:

Beratergremium für umweltrelevante Altstoffe der Gesellschaft Deutscher Chemiker (BUA)

Year:

1992

Bibliographic source:

Hirzel Verlag, Stuttgart

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

ISO 6341 (Water quality - Determination of the Inhibition of the Mobility of Daphnia magna Straus (Cladocera, Crustacea))

Deviations:

no

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetrachloro-p-benzoquinone

EC Number:

204-274-4

EC Name:

Tetrachloro-p-benzoquinone

Cas Number:

118-75-2

Molecular formula:

C6Cl4O2

IUPAC Name:

2,3,5,6-tetrachloro-1,4-benzoquinone

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

not specified

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

24 h

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

< 0.36 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: (65% immobile daphnids at 0.36 mg/L)

Effect concentrations 2

Duration:

24 h

Dose descriptor:

EC100

Effect conc.:

0.72 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

24-h EC50 in a reference test with potassium dichromat was 1.0 mg/L (the results of inter laboratory tests and a Technical Corrigendum to ISO 6341 give an EC50-24 h of the potassium dichromate (K2Cr2O7) within the range 0.6 mg/L to 2.1 mg/L)

Conclusions:

The 48h-EC50 determined in this study was < 0.36 mg/L

Executive summary:

In a 24-h toxicity study, daphnids (Daphnia magna) were exposed toChloranil (2,3,5,6-tetrachloro-1,4-benzoquinone)at nominal concentrations of 0 (control), 0.36 and 0.72 mg/L under static conditions in accordance ISO 6341. The test material was delivered to the testing laboratory as a solution (nominal 0.72 mg/L in testing water) and no analytical monitoring was performed. The basis for effect was immobilization. The 24-hour EC50 was <0.36 mg/L. At 0.36 mg/L, immobilization amounted to 65%. The 24-hour EC100 based on immobilization was 0.72 mg/L.