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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Information is available for the registered substance from two reliable in vitro tests in bacteria. As there was more than one reliable study, the most recent study was selected. Both the studies were in agreement. For endpoints where reliable studies were not available for the test substances, studies for related substances were selected. The result from the two in vitro studies were in agreement, but gave a different conclusion from the bacterial mutagenicity study. An in vivo micronucleus study is available for one of the related substances, which did not confirm the positive result obtained in the in vitro chromosome aberration studies.


Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without activation in all strains tested (similar to OECD TG 471)
Cytogenicity in mammalian cells: weight of evidence from:
read-across from analogous substance trimethoxvinylsilane, CAS 2768-02-7: positive with and without activation in CHL/IU cells (OECD TG 473)
read-across from related substance butan-2-one O,O',O''-(vinylsilylidyne)trioxime, CAS 2224-33-1: positive with and without activation in CHOcells (OECD TG 473)
Mutagenicity in mammalian cells: INFORMATION AVAILABLE?
In vivo:
read-across from analogous substance trimethoxvinylsilane, CAS 2768-02-7: negative in mouse micronucleus test, ip administration (US EPA guideline test, similar to OECD TG 474)

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The available information for Trichloro(vinyl)silane indicates that when tested in vitro, Trichloro(vinyl)silane (CAS number 75 -94 -5) does not induce mutations in bacterial cells. The related substances butan-2-one O,O',O''-(vinylsilylidyne)trioxime (CAS number 2224 -33 -1) and trimethoxyvinylsilane (CAS number 27868 -02 -7) caused chromosomal aberrations in vitro in the presence and absence of metabolic activation, but this was not confirmed in an in vivo study, so it is concluded that trichloro(vinyl)silane is not genotoxic.