Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: The result is sourced from secondary literature (IUCLID 2000 data set). The original reference was not available for review and no further information is available.

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
No information
Author:
IUCLID dataset
Year:
1946
Bibliographic source:
European Commission, European Chemicals Bureau, IUCLID Dataset: Trichloro(vinyl)silane (CAS 75-94-5). 2000
Reference Type:
publication
Title:
No information
Author:
Smyth, HF
Year:
1954
Bibliographic source:
A.M.A. Arch. Ind. Hyg. Occup. Med., 10; 61-68 cited in IUCLID 2000

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
other: propylene glycol (or water)
Controls:
not specified
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
Noo data

Results and discussion

In vivo

Results
Irritation parameter:
cornea opacity score
Remarks on result:
other: Corrosion, grade 10 of 10
Other effects:
None reported

Applicant's summary and conclusion

Conclusions:
In a very limited IUCLID 2000 eye irritation study (reliability score 4) summary 0.5 ml of a 1% solution of trichloro(vinyl)silane (in propylene glycol or water) was corrosive to the eyes of rabbits.
Executive summary:

In a very limited IUCLID 2000 eye irritation study summary 0.5 ml of a 1% solution of trichloro(vinyl)silane (in propylene glycol or water) was corrosive to the eyes of rabbits. No further details are available.