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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 203-620-1 | CAS number: 108-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- refer to category document
Data source
Reference
- Reference Type:
- publication
- Title:
- Percutaneous uptake and kinetics of methyl isobutyl ketone (MIBK) in the guinea pig
- Author:
- Hjelm EW, Boman A, Fernström P , Hagberg M and Johanson G
- Year:
- 1 991
- Bibliographic source:
- Toxicol Letters, 56, 79–86
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Quantitative estimation of the percutaneous uptake rate and toxicokinetics of MIBK in the guinea-pig
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methylpentan-2-one
- EC Number:
- 203-550-1
- EC Name:
- 4-methylpentan-2-one
- Cas Number:
- 108-10-1
- Molecular formula:
- C6H12O
- IUPAC Name:
- 4-methylpentan-2-one
Constituent 1
- Specific details on test material used for the study:
- - Supplier: Aldrich
- Purity: 99.7% - Radiolabelling:
- no
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: J.A. Sahlin, Malmb, Sweden
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: Makrolon cages
- Individual metabolism cages: no data
- Diet (ad libitum): standard pelleted food for guinea-pig and rabbit breeding (Ewos, S6dertlje, Sweden)
- Water (ad libitum): tap water
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- up to the end of the experiment
- Doses:
- 1 ml
- No. of animals per group:
- 8
- Control animals:
- no
- Details on study design:
- The hair on the back of the animal was clipped and one glass cylinder with an internat area of 3.14 cm2 was glued with cyanoacrylate to the skin. At 150-190 min after termination of the infusion a `blank' blood sample was collected and the cylinder on the back of the animal was then filled with 1 ml of neat MIBK and subsequently sealed by gluing a glass lid on top of it. Blood samples were collected at 5, 10 and 15 min and then every 15 min until 150 min after onset of exposure.
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
Percutaneous absorption
- Remarks on result:
- other: Percutaneous uptake rate in guinea pigs exposed epicutaneously to MIBK peaked at 10 to 45 minutes after the onset of a 150-minute exposure; the maximum uptake rate ranged from 0.11 to 2.0 µmol/min/cm and averaged 1.1 µmol/min/cm.
Any other information on results incl. tables
During epicutaneous exposure the concentration of MIBK in blood rose rapidly and reached a maximum concentration after 10-45 min and then started to decline in spite of continuons exposure (Fig. 1). Large individual variations in blood concentrations were observed during epicutaneous exposure; the maximum concentration ranged between 7 and 55 µmol/l (Table II). The maximum percutaneous uptake rate for all animals averaged 1.1 (range 0.15-2.2) µmol.min-1.cm-2 and was reached 10-45 min after onset of exposure. The mean uptake rate 15-75 min after onset of exposure was 0.86 (range 0.11-2.0) µmol.min-1.cm-2. Later during the exposure, at 75-135 min, the uptake rate decreased to 0.56 (range 0.084-1.5) µmol.min-1.cm-2. This decrease, which was observed in all experiments, averaged 34% (range 20-47%) (Table II).
Applicant's summary and conclusion
- Executive summary:
The percutaneous uptake rate in guinea pigs exposed epicutaneously to MIBK peaked at 10 to 45 minutes after the onset of a 150-minute exposure; the maximum uptake rate ranged from 0.11 to 2.0 µmol/min/cm and averaged 1.1 µmol/min/cm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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