Fatty acids, tall-oil, polymers with glycidyl neodecanoate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

not specified

Type of method:

flask method

Key result

Water solubility:

>= 15.6 - <= 40.2 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

Remarks on result:

other: no information on pH available

Details on results:

As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 304 – 1,004 mg/L was 15.6 – 40.2 mg/L at 20.0±0.5°C (15.6 – 40.2 X 10E-03 kg/m3 in SI units). Therefore, 4.5% of the test substance (mean value) was dissolved in water relating to the nominal concentration of the test substance.

Measurements during equilibration

The data which was acquired during equilibration time (flasks 1A-C) is presented in the following table:

Table 1: Measurements during equilibration

Day	Temperature [°C]	pH	Measured DOC values [mg/L]	Concentration of test substance [mg/L]	Difference to previous sample
1	20.0	5-6	16.5	22.5	-
2	20.0	5-6	16.2	22.1	-2.0%
3	20.0	5-6	16.4	22.5	1.7%

 

The TC content of the test substance was determined in the laboratory Mikroanalytisches Labor Pascher (D-53424 Remagen) with 73.14% and the value was used in the calculation of the test substance concentration from the measured DOC concentration. The measured value in the blank flask lay below the LOQ of TC (<1.60 mg/L). After the analysis of the Day 3 sample, the plateau was considered as reached.

Measurements at plateau

The following table gives the values which were measured at the plateau.

Table 2: Measurements of Plateau

Flask	2	3	4	5	6
pH	6.09	5.81	6.03	5.95	6.13
Measured DOC values [mg/L]	19.8	11.4	19.9	24.1	29.4
C content [%]	73.14	73.14	73.14	73.14	73.14
Concentration of the test substance [mg/L]	27.1	15.6	27.3	32.9	40.2
Nominal concentration of the test substance [mg/L]	104	304	600	800	1004

 

Temperature was measured with 20.0±0.5°C.

All measurements on Day 3 (flasks 1A – 1C and 2 – 6) were included in the calculation of the solubility of the test substance in water.

Table 3: Measurements used for calculation of solubility

Flask	Measured concentration of test substance [mg/L]	Nominal concentration of test substance [mg/L]	Dissolved part [%]
2*	27.1	104	26.1
3	15.6	304	5.1
1**	22.4	501	4.5
4	27.3	600	4.5
5	32.9	800	4.1
6	40.2	1004	4.0

*the value was stated as outlier and was not used in the calculation of the mean (Grubbs outlier test of the dissolved part).

**mean value of flasks 1A-1C

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility range for the tested nominal concentrations of 304 - 1,004 mg/L was 15.6 - 40.2 mg/L at 20.0±0.5°C.

Executive summary:

A study was conducted to evaluate the water solubility of the test substance according to OECD Guideline 105 and EU Method A.6 using the flask method. Solubility was determined from the measured concentrations of dissolved organic carbon in filtered test solutions. In the preliminary test, flasks with nominal concentrations 10 and 1,000 mg/L were shaken at room temperature for 3 d and measured for DOC. Values of <1.6 and 29.0 mg/L dissolved organic carbon (DOC) were measured in the flasks at nominal concentrations of 10 and 1,000 mg/L, respectively. In the main test, six different nominal concentrations of test substance (100, 300, 500, 600, 800 and 1,000 mg/L) were chosen to study the effect of the loading rate on the measured water solubility. The flasks for the different concentrations were placed on a shaking apparatus for a predefined time. Samples were taken, membrane filtered and analysed for DOC via TOC analyser. No Tyndall effect (i.e., a laser beam was not scattered when transmitted through the liquid) could be observed, indicating that no colloidal dispersed particles were present. Linear dependency of solubility on amount of test substance (nominal load) was assessed in the main test. As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water could be stated. Under the study conditions, the solubility range for the tested nominal concentrations of 304 - 1,004 mg/L was 15.6 - 40.2 mg/L at 20.0±0.5°C (Affolter, 2015).

Description of key information

The water solubility was determined according to OECD Guideline 105 (flask method) (Affolter, 2015).

Key value for chemical safety assessment

Water solubility:

15.6 mg/L

at the temperature of:

20 °C