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EC number: 211-105-8
CAS number: 629-73-2
No significant effects were observed at any
dose level, with or without metabolic activation.
a reverse gene mutation assay in bacteria, strains TA 98, TA 100, TA
1535, TA 1537, and TA 1538 of S. typhimurium were exposed to
1-hexene in DMSO at concentrations of 1.5, 5, 15, 50, 150, or 500
μg/plate in the presence and absence of mammalian metabolic activation
using the plate-incorporation method.
-Hexene was tested up to cytotoxic concentrations (5000 μg/plate) in a
preliminary range-finding study and based on the results, the above
mentioned concentrations were tested in the mutagenicity study. No
substantial increases in revertant colony numbers of any of the five
tester strains were observed subsequent to treatment with 1-hexene at
any dose level, either in the presence or absence of metabolic
was no evidence of induced mutant colonies over background or a
concentration related positive response observed during the study. The
positive controls induced the appropriate responses in the corresponding
study received a Klimisch score of 1 and is classified as reliable
without restriction because it is in compliance with GLPs and an
accepted concurrent guideline for reversion assays.
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