Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
211-105-8
CAS no.:
629-73-2
Index number:
Molecular formula:
C16H32
SMILES:
CCCCCCCCCCCCCCC=C
InChI:
InChI=1S/C16H32/c1-3-5-7-9-11-13-15-16-14-12-10-8-6-4-2/h3H,1,4-16H2,2H3
Type of substance:
Mono constituent substance, UVCB
Origin:
Organic, Petroleum product
Registered compositions:
16
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance may be fatal if swallowed and enters airways.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is very toxic to aquatic life with long lasting effects and causes serious eye irritation.

Breakdown of all 952 C&L notifications submitted to ECHA

Asp. Tox. 1 H304
Eye Irrit. 2 H319
Aquatic Chronic 1 H410
STOT SE 3 H335
Not Classified
STOT SE 3 H336
Flam. Liq. 3 H226
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • PBT
Under assessment as Persistent, Bioaccumulative and Toxic (PBT list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 19 active registrations under REACH, 3 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, adhesives and sealants and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: cosmetics and personal care products.

This substance is used for the manufacture of: .

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and closed processes with no likelihood of exposure.

Other release to the environment of this substance is likely to occur from: outdoor use as processing aid, indoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: polymers and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers, laboratory work and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following products: laboratory chemicals and polymers.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates) and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Do not induce vomiting. If on skin: wash with soap and water.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BD&I_37, rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Phillips Chemicals International N.V. - OR CPC, Airport Plaza, Stockholm Building Da Vincilaan 19 1831 Diegem Belgium
  • Dow Silicones Belgium SPRL OR-2, Rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • INEOS Feluy SA (OR Chocolate Bayou), Parc Industriel de Feluy Nord Zone C B-7181 Feluy Feluy Belgium
  • Ineos Feluy SPRL, Parc Industriel de Feluy Nord Zone C B-7181 Feluy Feluy Belgium
  • Ineos Feluy SPRL (OR Joffre), Parc Industriel de Feluy Nord Zone C B-7181 Feluy Belgium
  • KCC Europe GmbH, Hansaring 61 50670 Köln Germany
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Muntajat B.V. - QCHEMII, 19th Floor, Tower E, WTC The Hague Prinses Margrietplantsoen 78-A 2595 The Hague Netherlands
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • Sasol Germany GmbH, Anckelmannsplatz 1 D-20537 Hamburg Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • Shell Chemicals UK Limited, Shell Centre York Road SE1 7NA London London United Kingdom

Substance names and other identifiers

Hexadec-1-ene
EC Inventory, REACH pre-registration
Hexadec-1-ene
REACH pre-registration, Other
1-Hexadecen
C&L Inventory
1-HEXADECENE
C&L Inventory, Registration dossier
1-Hexadecene
C&L Inventory, Registration dossier
AlphaPlus C16 IS
Registration dossier
C16
Registration dossier
Hexadec-1-ene
C&L Inventory, Registration dossier, Other
Hexadec-1-ene
C&L Inventory, Registration dossier, Other
hexadec-1-ene (UVCB)
Registration dossier
Hexadecene
C&L Inventory, Registration dossier
hexadecene
Registration dossier
Hexadecene-1
C&L Inventory
hexadecene-1
Registration dossier
Linealene 16
Registration dossier
n-Hexadec-1-ene
C&L Inventory
NEODENE 16
Registration dossier
Linealene 16
Registration dossier
NEODENE 16
Registration dossier
501012-99-3
CAS number
Other
629-73-2
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 88 studies submitted
  • 76 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (92%), Solid (8%) [76]
C Form
Not specified (81%), Other (13%) [62]
C Odour
Other (100%) [46]
C Substance type
Organic (86%), Other (10%) [58]

Type of Study provided
Studies with data
Key study 76
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 50 studies submitted
  • 34 studies processed
R Melting / freezing point
-133 - 68.333 °C @ 101.3 - 101.325 kPa [34]

Type of Study provided
Studies with data
Key study 34
Supporting study 14
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
2.1 °C

Boiling point

Study results
  • 82 studies submitted
  • 48 studies processed
R Boiling point
60 - 367 °C @ 100.8 - 101.67 kPa [50]

Type of Study provided
Studies with data
Key study 50
Supporting study 4 16
Weight of evidence
Other 12
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
284.9 °C

Density

Study results
  • 70 studies submitted
  • 44 studies processed
R Density
0.67 - 0.82 g/cm³ @ 20 - 35 °C [44]
R Relative density
0.67 - 0.76 @ 20 °C [4]

Type of Study provided
Studies with data
Key study 54
Supporting study 14
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.781

Vapour pressure

Study results
  • 58 studies submitted
  • 34 studies processed
R Vapour pressure
0.017 - 62 000 Pa @ 20 - 171.111 °C [54]

Type of Study provided
Studies with data
Key study 34
Supporting study 12
Weight of evidence
Other 12
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0.123 Pa @ 25 °C

Partition coefficient

Study results
  • 150 studies submitted
  • 66 studies processed
R Log Pow
1.5 - 13.96 @ 20 - 25 °C and pH 5.4 - 7 [70]

Type of Study provided
Studies with data
Key study 36 30
Supporting study 56 10
Weight of evidence
Other 18
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
8.06 @ 20 °C

Water solubility

Study results
  • 102 studies submitted
  • 46 studies processed
R Water solubility (mass/vol.)
0 - 88 500 000 ng/L @ 20 - 25 °C and pH 5.5 - 7.46 [50]

Type of Study provided
Studies with data
Key study 26 20
Supporting study 42 4
Weight of evidence
Other 10
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
1.44 µg/L @ 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 70 studies submitted
  • 50 studies processed
R Flash point
-25 - 218 °C @ 99.9 - 101.9 kPa [50]

Type of Study provided
Studies with data
Key study 50
Supporting study 14
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
132 °C

Auto flammability

Study results
  • 34 studies submitted
  • 18 studies processed
R Autoflammability / self-ignition
222 - 285 °C @ 101.3 - 103.2 kPa [18]

Type of Study provided
Studies with data
Key study 18
Supporting study 10
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
240 °C

Flammability

Study results
  • 14 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 6
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 50 studies submitted
  • 32 studies processed
R Other:
0.42 - 6.356 [14]
R dynamic viscosity (in mPa s)
0.202 - 5.04 [12]
R kinematic viscosity (in mm²/s)
0.66 - 19.3 [24]

Type of Study provided
Studies with data
Key study 32
Supporting study 16
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
4.03 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 4 studies submitted
  • 4 studies processed
R Dissipation half life (DT50)
10.2 h [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 176 studies submitted
  • 62 studies processed
R BOD5
1.64 g O2/g test material [4]
R COD
2.81 g O2/g test material [4]
C Interpretation of results
Readily biodegradable (59%), Not readily biodegradable (31%), Readily biodegradable but failing the 10-day window (10%) [58]

Type of Study provided
Studies with data
Key study 42 38
Supporting study 48 48
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 140 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 36 36
Supporting study 34 34
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 56 studies submitted
  • 48 studies processed
R log Koc
2.59 - 6.63 dimensionless @ 20 °C [48]

Type of Study provided
Studies with data
Key study 2 28 26
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Koc at 20°C
4 265 795

Henrys law constant (H)

Study results
  • 48 studies submitted
  • 46 studies processed
R H - (pressure) m³/mol
10 800 - 1 122 150 Pa m³/mol @ 20 - 25 °C and 101.3 kPa [46]

Type of Study provided
Studies with data
Key study 24 24
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Henry's law constant
19 170 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1 µg/L (2)
Intermittent releases (freshwater) 1 µg/L (2)
Marine water 1 µg/L (2)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (2)
Sediment (freshwater) 426.58 mg/kg sediment dw (2)
Sediment (marine water) 426.58 mg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 85.3 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential to cause toxic effects if accumulated (in higher organisms) via the food chain (2)

Short–term toxicity to fish

Study results
  • 92 studies submitted
  • 24 studies processed
P/RResults
LC50 (4 days) 3.4 - 6 600 µg/L [24]
NOEC (4 days) 3.4 - 2 890 µg/L [12]

Type of Study provided
Studies with data
Key study 24 24
Supporting study 6 22 16
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 96 studies submitted
  • 12 studies processed
P/RResults
EC50 (48 h) 2.8 - 4 400 µg/L [12]
NOEC (48 h) 2.8 - 560 µg/L [8]

Type of Study provided
Studies with data
Key study 18 18
Supporting study 10 30 20
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
NOEC (21 days) 19.4 µg/L [4]
LOEC (21 days) 28.7 µg/L [4]
EC50 (21 days) 28.1 µg/L [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 104 studies submitted
  • 12 studies processed
P/RResults
EC50 (4 days) 4.5 - 5.5 mg/L [12]
EC50 (72 h) 930 - 1 800 000 ng/L [8]
NOEC (4 days) 230 - 1 800 µg/L [12]
NOEC (72 h) 930 ng/L [4]

Type of Study provided
Studies with data
Key study 20 20
Supporting study 12 32 20
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 92 studies submitted
  • 40 studies processed
P/RResults
EC50 (3 h) 1 g/L [4]
NOEC (28 days) 2 mg/L [16]
NOEC (14 days) 2 - 17.1 mg/L [12]
NOEC (5 days) 2 - 3 mg/L [8]
NOEC (3 h) 1 g/L [4]

Type of Study provided
Studies with data
Key study 28 28
Supporting study 18 18
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 46 studies submitted
  • 12 studies processed
P/RResults
LC50 (10 days) 182 - 4 780 mg/kg sediment dw [24]

Type of Study provided
Studies with data
Key study 8 8
Supporting study 14 14
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 12 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 4 4
Supporting study 12 12
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 92 studies submitted
  • 56 studies processed
P/RResults
LD50 2 000 - 10 000 mg/kg bw (rat) [36]
LD50 5 mL/kg bw (rat) [4]
approx. LD50 10 mL/kg bw (rat) [8]
M/CInterpretations of results
Study cannot be used for classification [4]

Type of Study provided
oral
Studies with data
Key study 30 26
Supporting study 18 18
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 80 studies submitted
  • 52 studies processed
P/RResults
LC50 (6 h) 46.3 mg/L air (rat) [4]
LC50 (4 h) 2.1 mg/L air (rat) [4]
LC50 (4 h) 8 050 ppm (rat) [4]
LC50 (6 h) 46.3 mg/L air (mouse) [4]
LC50 (6 h) 46.3 mg/L air (guinea pig) [4]
M/CInterpretations of results
Other [52]

inhalation
Studies with data
Key study 8 8
Supporting study 14 14
Weight of evidence 18 18
Other
Data waiving
no waivers
dermal
  • 88 studies submitted
  • 48 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [12]
LD50 4 mL/kg bw (rat) [4]
approx. LD50 2 - 4 mL/kg bw (rat) [4]
LD50 2 000 - 10 000 mg/kg bw (rabbit) [12]
LD50 2 mL/kg bw (rabbit) [4]
M/CInterpretations of results
Category 5 based on GHS criteria [8]

dermal
Studies with data
Key study 24 24
Supporting study 20 20
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 28 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study 14 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 148 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 32 32
Supporting study 40 44
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 109 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 36 33
Supporting study 20 20
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 62 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 28 28
Supporting study 2 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 158 studies submitted
  • 36 studies processed
P/RResults
NOAEL (rat): 500 - 1 000 mg/kg bw/day [18]
NOEL (rat): 20 - 1 000 mg/kg bw/day [30]
LOEL (rat): 20 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 12 24
Supporting study 42 78
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 16 studies submitted
  • 4 studies processed
P/RResults
NOAEC (rat): 3 000 ppm [4]

Study data: inhalation
Studies with data
Key study 4
Supporting study 4 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Study data: dermal
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 4 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 120 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 52 52
Supporting study 8 8
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 12 8
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 64 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 4
Supporting study 16 32
Weight of evidence
Other 10
Data waiving
no waivers
Study data: developmental
  • 94 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 4
Supporting study 26 52
Weight of evidence
Other 10
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 300 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Study results
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 12 12
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant