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The aquatic toxicity of the test compoundwas studied in an acute immobilization test with Daphnia magna (limit test). The daphnids were exposed to a saturated solution of the test compound for 48 hours. 2 daphnids (10%) were immobilized between 24 and 48 hours. This was assumed to be spontaneous, since up to 10% immobilized daphnids are accepted for the control group.The test concentration was determined by TOC analysis with 6.2 mg/L. Thus the EC50/48 h was higher than a saturated solution of hydrocortison-21-acetate with 6.2 mg/L.The study was conducted under GLP (see report no. A08680). An earlier limit test confirmed these observations (Schering study no.TX91307).

The toxicity to activated sludge miccroorganisms was studied in a respiration inhibition test according to OECD 209. The microorganisms were incubated for 30 min with the test compound at a nominal loading of 100 mg/L, which was above the solubility level. No inhibiton of respiration was observed. Therefore, the EC10/EC50 of hydrocortison-21 -acetate to activated sludge microorganisms is higher than 100 mg/L. The study was conducted under GLP (see Schering study no. TX91272).