Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-004-4 | CAS number: 50-03-3
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic toxicity of the test compoundwas studied in an acute immobilization test with Daphnia magna (limit test). The daphnids were exposed to a saturated solution of the test compound for 48 hours. 2 daphnids (10%) were immobilized between 24 and 48 hours. This was assumed to be spontaneous, since up to 10% immobilized daphnids are accepted for the control group.The test concentration was determined by TOC analysis with 6.2 mg/L. Thus the EC50/48 h was higher than a saturated solution of hydrocortison-21-acetate with 6.2 mg/L.The study was conducted under GLP (see report no. A08680). An earlier limit test confirmed these observations (Schering study no.TX91307).
The toxicity to activated sludge miccroorganisms was studied in a respiration inhibition test according to OECD 209. The microorganisms were incubated for 30 min with the test compound at a nominal loading of 100 mg/L, which was above the solubility level. No inhibiton of respiration was observed. Therefore, the EC10/EC50 of hydrocortison-21 -acetate to activated sludge microorganisms is higher than 100 mg/L. The study was conducted under GLP (see Schering study no. TX91272).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
