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Environmental fate & pathways

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The aerobic biodegradation was studied in a CO2 evolution test according to OECD 301B. The test compound was incubated at concentrations of 10 and 20 mg/L over 28 days. At both concentrations, the test compound was degraded to more than 70% at the end of the incubation period. 60% degradation was reached at day 11, which was less than 5 days after the start of the degradation (i.e.10% degradation). Therefore, hydrocortison acetate is ready biodegradable. The reference compound, sodium acetate, was degraded to more than 60% on s´day 8, fulfilling the validity criteria. The study was conducted under GLP (Schering study no. TX92010).