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Vapour pressure

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Valid experimental study (pretest type data) with use of a vapour pressure balance (Knudsen effusion method as described in EU testing guideline A.4). Analytical Development Physical Chemistry, Schering AG Berlin. Study report No. A05410 (ADP 2001_167), author F. Lopez, dated 2001-09-03
Result: The vapour pressure of Hydrocortisone-21-acetate at 25°C is < 0.001 Pa.

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Additional information

The vapour pressure of Hydrocortisone-21-acetate was determined using a screening method based on the detection of the evaporation rate from a Knudsen cell of a vapour pressure balance at 25°C.

Hydrocortisone-21-acetate was mixed with four other compounds. From all five test substances low or very low vapour pressures, based on the study directors experience were expected. For this reason the experiments consisted in the measurement of the evaporation rate of the mixture from a Knudsen cell at 25°C. Since the evaporation rate of the mixture was below the value derived from the lower limit of the vapour pressure range recommended for use of a vapour pressure balance (10-3Pa, EU testing guideline A.4) it can be assumed that the vapour pressure of the mixture is lower than 10-3Pa.

 

Considering this this fact, the vapour pressure of the single compounds in the mixture has also to be lower than 10-3Pa.

Therefore, the vapour pressure of Hydrocortisone-21-acetate can be estimated to be at 25°C :

p25 < 10-3Pa