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EC number: 222-746-8 | CAS number: 3598-16-1
Phenoxyacetic acid (and two structurally related compounds) were suspended in a 1:1 solution of honey:water and administered by gavage to pregnant mice on one of gestation days 8-15 (copulation plug day = day 1) or on three consecutive days (7-9, 10-12, or 13-15). Doses were 800-900 mg/kg for single and 250-300 mg/kg/day for multiple treatments. No increased prenatal mortality, and no decreased fetal weight were observed compared to the solvent controls. Low incidences, not gaining significance, of increased cleft palate or other gross malformations were seen in all treatment groups. Significant skeletal, visceral or histopathological defects were not observed.
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