Registration Dossier

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Hydrolysis

The hydrolysis rate constant and half-life of hydrolysis of test chemical was estimated by EPI Suite (HydroWin). The Hydrolysis rate constant estimated was 0.0465 L/mol/Sec at pH greater than 8. The Half-life at pH 8 estimated was 172.299 days and half-life at pH 7 estimated was 4.717 years. Since, half-life of hydrolysis of test chemical is very high, it shows negligible hydrolysis in water.

 

Additional information

Hydrolysis

Predicted data for the test chemical and supporting experimental weight of evidence studies for its structurally similar read across substancewere reviewed for the hydrolysis end point which are summarized as below:

 

The hydrolysis rate constant and half-life of hydrolysis of test chemical was estimated by EPI Suite (HydroWin). The Hydrolysis rate constant estimated was 0.0465 L/mol/Sec at pH greater than 8. The Half-life at pH 8 estimated was 172.299 days and half-life at pH 7 estimated was 4.717 years. Since, half-life of hydrolysis of test chemical is very high, it shows negligible hydrolysis in water.

 

In other study, the test chemical showed half-life of 1.8 years at pH 8 and at temperature 10 degree C. Based on the half-life, the test chemical shows negligible hydrolysis.

                               

The half-life of the test chemical was determined using an estimated pseudo-first order hydrolysis rate constant of 0.00000021/sec. The half-life of test chemical was determined to be 38 days at pH 7 and a temperature of 25°C, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the hydrolysis half-life value was determined. The half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the available experimental studies, it can be concluded that the test chemical undergoes negligible hydrolysis in water.