Registration Dossier
Registration Dossier
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EC number: 635-476-4 | CAS number: 88349-88-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Three acute fish toxicity studies have been conducted, the results are presented below:
The first study determined the acute toxicity of CGA 153433 T (cloquintocet-acid) to rainbow trout (Oncorhynchus mykiss, formerly known as Salmo gairdneri). The study was carried out according to OECD guideline 203 (1984). The fish were exposed to the CGA 153433 T for 96 hours under static conditions. Nominal concentrations were 0 (control), 10, 18, 32, 58 and 100 mg/L, the corresponding mean measured concentrations were 0, 10.1, 17.65, 31.75, 56.45 and 99.3 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was calculated to be 89.7 mg/ with 95% confidence intervals of 74.5 to 113 mg/L. The corresponding no-observed effect concentration was 18 mg/L.
The second study determined the acute toxicity of CGA 153433 T (cloquintocet-acid) to common carp. The study was carried out according to OECD guideline 203 (1984). The fish were exposed to the CGA 153433 T ofor 96 hours under static conditions. Nominal concentrations were 0 (control), 10, 18, 32, 58 and 100 mg/L, the corresponding mean measured concentrations were 0, 10.2, 18.85, 28.75, 58.55 and 97.75 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was calculated to be 90 mg/L with 95% confidence intervals of 74 to 113 mg/L. The corresponding no-observed effect concentration was 58 mg/L.
The third study determined the acute toxicity of XDE-558 (cloquintocet-acid) to sheepshead minnow (Cyprinodon variegatus), a salt-water species. The study was carried out according to OECD guideline 203 (1984) and OPPTS 850.1075. The fish were exposed to XDE-558 for 96 hours under semi-static conditions, with test medium renewal after 48 hours. Nominal concentrations were 0 (control) and 120 mg/L, the corresponding mean measured concentrations were 0 and 122 mg/L, respectively. As the measured concentrations were within 20% of the nominal concentrations the results of the study are expressed in terms of nominal exposure.
The 96 hour LC50 was observed to be >120 mg/L, the corresponding no-observed effect concentration was 120 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 89.7 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 120 mg/L
Additional information
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