Phosphorus tribromide

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

Data from NTRL report

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Short term toxicity test was performed in Daphnia magna for 48 hrs at different concentrations.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phosphorus tribromide
- Molecular formula : Br3P
- Molecular weight : 270.686 g/mol
- Smiles notation : P(Br)(Br)Br
- InChl : 1S/Br3P/c14(
2)3
- Substance type: Inorganic
- Physical state: Liquid

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Water flea

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Hardness:

88 mg/L

Test temperature:

20 ±2 °C

Nominal and measured concentrations:

nominal concentration: 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L

Duration:

48 h

Dose descriptor:

NOEC

Effect conc.:

6.25 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

22.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

not specified

Validity criteria fulfilled:

not specified

Conclusions:

The endpoint for the Phosphorus tribromide (7789-60-8) for short term toxicity to aquatic invertebrates was determined to be NOEC and EC50 value at 6.25 mg/l and 22.6 mg/lconcentration

Executive summary:

Short term toxicity to aquatic invertebrates was performed at different concentrations as0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L. Experiment performed in static condition in fresh water for 48 hrs. Mortality was observed and effective concentration was found to be 22.6 mg/L (18.2 - 27.9 mg/L confidence limit).

Therefore,the endpoint for the Phosphorus tribromide (7789-60-8) for short term toxicity to aquatic invertebrates was found to be NOEC and EC50 value at 6.25 mg/l and 22.6 mg/l concentration.

Based on the value, the Phosphorus trichloride was considered to be toxic to aquatic invertebrates and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Description of key information

Short term toxicity to aquatic invertebrates was performed from HSDB,2016 and NTRL report, 1997 for phosphorus tribromide at different concentrations as 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L. Experiment performed in static condition in fresh water for 48 hrs. Mortality was observed and effective concentration was determined to be 22.6 mg/L (18.2 - 27.9 mg/L confidence limit). Therefore, the endpoint for the Phosphorus tribromide (7789-60-8) for short term toxicity to aquatic invertebrates was determined to be NOEC and EC50 value at 6.25 mg/l and 22.6 mg/l concentration. Based on the value, the Phosphorus tribromide was considered to be toxic to aquatic invertebrates and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

22.6 mg/L

Additional information

Short term toxicity to aquatic invertebrates was summaries with one experimental study , one prediction for Phosphorus tribromide (7789-60-8) and one experimental study with read across.

Short term toxicity to aquatic invertebrates was performed from HSDB,2016 and NTRL report, 1997 for phosphorus tribromide at different concentrations as 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L. Experiment performed in static condition in fresh water for 48 hrs. Mortality was observed and effective concentration was determined to be 22.6 mg/L (18.2 - 27.9 mg/L confidence limit). Therefore, the endpoint for the Phosphorus tribromide (7789-60-8) for short term toxicity to aquatic invertebrates was determined to be NOEC and EC50 value at 6.25 mg/l and 22.6 mg/l concentration. Based on the value, the Phosphorus tribromide was considered to be toxic to aquatic invertebrates and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Using the EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be72.88mg/l for Phosphorus tribromide (7789-60-8) in 48 hrs. Based on the value, the Phosphorus tribromide was considered to be toxic to aquatic invertebrates and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Study on read across Phosphorus trichloride (7719-12-2) from SIDS Assessment Report, 2004 in Daphnia magna for 48 hrs at different six concentrations along with control. The test was performed without feeding to Daphnia magna. 10 neonates were taken for each concentration at 18-20 degree C temperature. pH and oxygen values measured at the end of the test. After the experiment, the EC 50 value for Phosphorus trichloride (7719-12-2) was determined to be 35.4 mg/l.

Based on the above data for the target and functionally related read across chemicals, it can be considered the substance was considered to be toxic to aquatic invertebrates andcan be classified in aquatic chronic 3 as per the CLP regulations.