Phosphorus tribromide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Qualifier:

according to guideline

Guideline:

other: refer below principle

Principles of method if other than guideline:

Acute aquatic toxicity determine of test substance Phosphorus tribromide (PBr3) for 96 hrs exposure period.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material (as cited in study report): Phosphorus tribromide
- Molecular formula: Br3P
- Molecular weight: 270.686 g/mol
- Smiles notation: P(Br)(Br)Br
- InChl : 1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Liquid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Pimephales promelas

Details on test organisms:

TEST ORGANISM
- Common name:fathead minnows

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

88 mg/L hardness as CaC03

Test temperature:

22 ±2 °C

Nominal and measured concentrations:

0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L

Details on test conditions:

- No. of organisms per vessel:10 per group
- The static tests were performed in replicate and the results were pooled.

Reference substance (positive control):

not specified

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

71 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 50 -100 mg/L confidence limit

Duration:

96 h

Dose descriptor:

NOEC

Effect conc.:

25 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Validity criteria fulfilled:

not specified

Conclusions:

In acute fish toxicity study the 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L was observed.

Executive summary:

In Acute aquatic toxicity tests on fathead minnows(Pimephales promelas)Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.

Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Description of key information

In Acute aquatic toxicity tests on fathead minnows(Pimephales promelas)Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.

Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

71 mg/L

Additional information

Two studies including experimental data from reliable data source of short term fish toxicity endpoint for Phosphorus tribromide (7789-60-8) with relevant read across chemical which is structurally similar to target were summarized as follows:

First study from NTRL report, Human Effectiveness Directorate Deployment and Sustainment Division Operational Toxicology Branch, UNITED STATES AIR FORCE RESEARCH LABORATORY, 1997 and HSDB authorative database indicate that acute aquatic toxicity tests were conducted on fathead minnows (Pimephales promelas). Fathead minnows (10 per group) were exposed to 0.0, 6.25, 12.5, 25.0, 50.0 or 100.0 mg/L PBr3 in fresh water (88 mg/L hardness as CaC03) at 22 ±2 °C. The static tests were performed in replicate and the results were pooled. The 96-hour LC50 value for fathead minnow was 71 mg/L (50 -100 mg/L confidence limit) and the no observed effect concentration (NOEC) was 25 mg/L.

Based on the lethal concentration (LC50) value the Phosphorus tribromide was considered to be toxic to fish and can be considered to be classified in aquatic chronic 3 category a per the CLP regulations.

Above aquatic classification of target chemical supported by read across chemical Phosphorus trichloride (Cas no. 7719-12-2) study from authorative database (HSDB by US EPA; 2017) which indicate in short term fish toxicity the lethal concentration (LC100) was observed to be 65 mg/l in fish species sturgeon (Acipenser), carp (Cyprinus carpio), perch (Percidae), Esox lucius (northern pike), and Leuciscus leuciscus (dace).The mentioned lethal concentration indicate that the test substance Phosphorus trichloride toxic to fish.

Based on the both studies concluded that the test chemical Phosphorus tribromide (7789-60-8) toxic to fish for short exposure period.