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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13. July to 14. Aug 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-methoxyoestra-1,3,5(10)-trien-17-one
EC Number:
216-613-3
EC Name:
3-methoxyoestra-1,3,5(10)-trien-17-one
Cas Number:
24508-10-9
Molecular formula:
C19 H24 O2
IUPAC Name:
3-methoxy-1,3,5(10)-estratriene-17β-ol
Test material form:
solid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Type of coverage:
not specified
Vehicle:
physiological saline
Duration of exposure:
24 hours
Doses:
2000 mg/kg
No. of animals per sex per dose:
3/sex
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality occurred
Clinical signs:
The test substance was tolerated without any clinical findings.
Body weight:
no effects observed
Gross pathology:
The test substance was tolerated without any macroscopic pathological findings.

Applicant's summary and conclusion

Interpretation of results:
other: no substance related mortality observed
Conclusions:
The acute dermal toxicity of estrone methylether is above 2000 mg/kg body weight.
Executive summary:

The single dermal, 24 h-administration of the test item to male and female Wistar rats at the dose of 2000 mg/kg was tolerated without any clinical or macroscopic pathological findings. The acute dermal toxicity of the test item is above 2000 mg/kg body weight.