Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: A scientifically sound paper
Data source
Reference
- Reference Type:
- publication
- Title:
- Chemical Burns Caused by Trifluoroacetic Acid
- Author:
- Dahlin L et al
- Year:
- 2 013
- Bibliographic source:
- Contact Dermatitis 69, 176-180
- Report date:
- 2012
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin irritation / corrosion
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- case reports
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 5
- Sex: male and female
- Age: 22 - 48 years
- Race: not indicated, not relevant - Ethical approval:
- not applicable
- Route of exposure:
- dermal
- Reason of exposure:
- other: unintential occupational and non-occupational
- Examinations:
- Five patients with chemical skin burns caused by the test substance were reviewed with regard to the extent of the burn, treatment, blood samples taken, and systemic effects.
Results and discussion
- Clinical signs:
- No clinical signs were observed except for the expected local skin corrosion effects.
Any other information on results incl. tables
The chemical burns reported were limited (< 1 % of the total body surface). The burns healed as expected for chemical burns caused by acids. None of the patients showed any symptoms or signs that are typical for hydrofluoric acid (the test substance has been suspected to have similar toxic effects as hydrofluoric acid on skin contact).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
