Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Endpoint summary
Administrative data
Description of key information
There are no data available concerning the skin sensitisation potential of trifluoroacetic acid (CAS 76-05-1). Since the substance is classified with H314, testing for skin sensitization is not required (Regultion 1907/2006, Annex VII, Column 2, Section 8.3).
In approximation, read across from the structurally similar compound, ethyl trifluoroacetate (CAS 383-63-1), was used. This substance is appropriate for read-across as the ethyl group was not known to induce sensitisation. In a LLNA (in vivo) the read-across substance ethyl trifluoroacetate did not induce delayed contact hypersensitivity in the murine Local Lymph Node Assay (stimulation index < 1).
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remarks'
- Remarks:
- The study as inserted into the disseminated ECHA dossier is a GLP and an OECD guideline study with a structurally similar compound, ethyl trifluoroacetate. This substance is appropriate for read-across as the ethyl group was not known to induce sensitisation.
- Parameter:
- SI
- Value:
- < 1
- Interpretation of results:
- not sensitising
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified as skin sensitiser under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
