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EC number: 206-788-4 | CAS number: 375-50-8
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 2017 to December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- static method
- Specific details on test material used for the study:
- - Appearance: Pink liquid
- Test item storage: At room temperature protected from light
- Purity/Composition correction factor: No correction factor required - Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 1 300 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 1 600 Pa
- Conclusions:
- The vapour pressure of the test item was 1300 Pa at 20°C and 1600 Pa at 25°C.
- Executive summary:
The vapour pressure of the test item was determined in a GLP-compliant study performed in accordancen with EC A.4 Method and OECD Guideline No. 104, using the static method. The vapour pressure of the test item was determined to be 1300 Pa at 20°C and 1600 Pa at 25°C.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The determination of the vapor pressure was performed according to a method specified in recognized guidelines (OECD 104 and EU Method A.4). In the study report there is no mention of a guidelines followed or GLP compliance. Some experimental information are missing (graph of log vapour pressure in function of the inverse function of the temperature, some raw data) so this study is considered reliable with restrictions.
- Qualifier:
- according to guideline
- Guideline:
- other: no guideline specified
- GLP compliance:
- no
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 20
- Vapour pressure:
- 3.8 mm Hg
- Vapour pressure:
- ca. 20 mm Hg
- Conclusions:
- The vapour pressure of the test substance is determined to be 3.8 mmHg at 20°C.
Referenceopen allclose all
The equation of the vapour pressure regression curve of the log PT of the test item as function of the temperatures was :
log PT= -1845 x 1/T + 9.40 (r = 0.9997, n = 12).
The results for the vapour pressure are given in Table 1 and Table 2.
Table 1: Results of the Vapour Pressure Static Method
Temperature[°C] |
PT [Pa] |
log PT |
50 |
4.9 x1000 |
3.69 |
|
4.9 x1000 |
3.69 |
60 |
7.4 x1000 |
3.87 |
|
7.6 x1000 |
3.88 |
70 |
1.05 x10000 |
4.02 |
|
1.08 x10000 |
4.03 |
80 |
1.49 x10000 |
4.17 |
|
1.53 x10000 |
4.18 |
90 |
2.08 x10000 |
4.32 |
|
2.10 x10000 |
4.32 |
100 |
2.90 x10000 |
4.46 |
|
2.90 x10000 |
4.46 |
VT : evaporation rate of the test item
PT :Vapour pressure
Table 2 : Vapour Pressure (PT) of the Test Item
Temperature |
logPT |
PT |
20 |
3.11 |
1.3x10 3 |
25 |
3.22 |
1.6x103 |
The vapour pressure by the static method was smaller than the value for water. This was unexpected, as during TGA analysis the weight loss of the test item was higher than the weight loss of water. During TGA analysis, the vapour pressure is determined indirectly comparing the weight loss of the test item to that of reference compounds, whereas the vapour pressure of the test item is measured directly using the Minivap VPSH. Therefore, data gathered with the Minivap VPSH was considered more reliable and the reported vapour pressure is based solely on this data.
Description of key information
The vapour pressure of the test item was determined in a GLP-compliant study performed in accordancen with EC A.4 Method and OECD Guideline No. 104, using the static method. The vapour pressure of the test item was determined to be 1300 Pa at 20°C and 1600 Pa at 25°C. These experimental values are further supported by a non-GLP study reporting a vapour pressure of ca. 506 Pa at 20°C.
Key value for chemical safety assessment
- Vapour pressure:
- 1 600 Pa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure of the test item was investigated in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint. A non-GLP study is also reported for the endpoint and selected as supporting study (Klimisch 2).
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