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EC number: 206-788-4 | CAS number: 375-50-8
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 2017 to December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Appearance: Pink liquid
- Test item storage: At room temperature protected from light
- Purity/Composition correction factor: No correction factor required - Key result
- Melting / freezing pt.:
- -4.1 °C
- Atm. press.:
- 1 018 hPa
- Decomposition:
- no
- Conclusions:
- The melting temperature of the test item was -4.1°C (269.1K).
- Executive summary:
The melting point of the test item was investigated in a GLP-compliant study performed in accordance with EC A.1 Method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). The melting point of the test item was determined to be -4.1°C.
- Endpoint:
- melting point/freezing point
- Type of information:
- other: literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Literature data coming from public database including a recognized database (SRC PhysProp Database part of EPISuite QSAR)
- Guideline:
- other: no guideline was specified in the differents literature data
- GLP compliance:
- not specified
- Type of method:
- other: method not specified
- Melting / freezing pt.:
- -9 °C
- Remarks on result:
- other: Atmospheric pressure not specified. Data coming from a recognized database: SRC PhysProp Database
- Conclusions:
- The freezing point of the test substance is -9°C
- Executive summary:
A data coming from a recognized international database (SRC PhysProp Database part of EPISuite QSAR) give a freezing point for the test substance of: -9°C.
- Endpoint:
- melting point/freezing point
- Type of information:
- other: literature data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information available
- GLP compliance:
- no
- Melting / freezing pt.:
- -9 °C
- Remarks on result:
- other: Pressure and decomposition products not reported
- Conclusions:
- A melting point of -9 °C was reported for DIOFB.
- Executive summary:
Only the result was reported and no information about the method used was provided; therefore the reliability of the data is not assignable.
- Endpoint:
- melting point/freezing point
- Type of information:
- other: literature data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No information available
- GLP compliance:
- no
- Melting / freezing pt.:
- -3 °C
- Remarks on result:
- other: Pressure not reported
- Conclusions:
- A melting point of -3 °C was reported for DIOFB.
- Executive summary:
Only the result was reported and no information about the method used was provided; therefore the reliability of the data is not assignable.
- Endpoint:
- melting point/freezing point
- Type of information:
- other: literature data
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Literature data coming from public database without sufficient documentation to assess reliability
- Guideline:
- other: no guideline was specified in the different literature data
- GLP compliance:
- not specified
- Type of method:
- other: method not specified
- Melting / freezing pt.:
- -9 °C
- Remarks on result:
- other: Atmospheric pressure not specified. Data coming from Yaws' Handbook of Physical Properties for Hydrocarbons and Chemicals 2008
- Melting / freezing pt.:
- -9 °C
- Remarks on result:
- other: Atmospheric pressure not specified. Data coming from Yaws' Critical Property Data for Chemical Engineers and Chemists 2012; 2013; 2014
- Melting / freezing pt.:
- -9 °C
- Remarks on result:
- other: Atmospheric pressure not specified. Data coming from Knovel Critical Tables (2nd Edition) 2008
- Conclusions:
- The freezing point of the test substance is -9°C
- Executive summary:
Three data coming from different literature sources give the same value for the freezing point of the test substance: -9°C.
Referenceopen allclose all
Preliminary Test
Starting at 100°C, the weight of the sample decreased significantly. At 142°C, the sample weight had decreased by 25%. After the experiment it was observed that the test item was evaporated from the samplecontainer.
Main study
In a first experiment, an exothermic peak between -20°C and 0°C was found during cooling (results are archived in the raw data). The effect was obtained due to crystallization of the test item. During heating, an endothermic peak was observed between -25°C and 25°C. The extrapolated onset temperature of the peak was -4.066°C. The endothermic effect was due to melting of the test item.
In order to investigate the melting peak, a second experiment was performed as a duplicate of the first experiment. Similar results as in the first experiment were obtained. The extrapolated onset of the melting peak was -4.044°C.
The melting temperature was determined as the mean melting temperature of the first experiment (-4.066°C) and second experiment (-4.044°C).
The freezing point for the test substance was specify to be -9°C in a literature source. This data comes from a recognized database : PHYSPROP (part of EPISuite QSAR)
No atmospheric pressure was indicated for the freezing point value. It is assumed that this parameter was determined at normal atmospheric pressure
The freezing point for the test substance was specify to be -9°C in three different literature sources.
No atmospheric pressure was indicated for the freezing point value. It is assumed that this parameter was determined at normal atmospheric pressure
Description of key information
The melting point of the test item was investigated in a GLP-compliant study performed in accordance with EC A.1 Method and OECD Guideline No. 102, using Differential Scanning Calorimetry (DSC). The melting point of the test item was determined to be -4.1°C. This experimental value is further supported by data from the literature.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- -4.1 °C
Additional information
The melting point of the test item was investigated in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint. Literature data are also reported for the endpoint and selected as supporting studies (Klimisch 2 or 4).
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