Registration Dossier
Registration Dossier
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EC number: 944-288-4 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on fish up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of the target substance Fatty acids, C8-12, isopentylesterto fish are not available. The assessment was therefore based on studies conducted with the analogue substances Isopropyl myristate (CAS 110-27-0) and isooctyl ester (CAS 84713-06-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification in IUCLID section 13.
The toxicity of the source substance Isopropyl myristate (CAS 110-27-0) to bluegill (Lepomis macrochirus) was tested according to EPA Guideline EPA 660/3-75-009 (Sousa et al. 1979). The static test was set up with the nominal test concentrations 78, 130, 220, 360, 600 and 1000 mg/L. There were no toxic effects observed in the species tested after an incubation period of 96 h up to 1000 mg/L, resulting in an LC50 (96 h) value of >1000 mg/L. After 24 and 48 h fish were observed to behave lethargic, however all fish recovered. Chemical flakes were observed to adhere to the glassware and tubes and/or collect as film at the surface. In a second study the acute toxicity of the source substance isooctyl ester (CAS 84713-06-4) to the Cyprinus carpio was tested under static conditions according to OECD guideline 203 (GLP). The test was conducted as a limit test at a substance concentration of 10000 mg/L (Bogers, 1997). Toxicity or symptoms of intoxication were not observed. At test termination after 96 hours of exposure a LC50 (96 h) > 10000 mg/L was determined.
Based on the results for the read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5),Fatty acids, C8-12, isopentylesteris considered not acutely toxic to fish up to the limit of water solubility.
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