Registration Dossier
Registration Dossier
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EC number: 944-288-4 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on microorganisms up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the toxicity of the target substanceFatty acids, C8-12, isopentylesterto aquatic microorganisms are not available. The assessment was therefore based on studies conducted with the structurally similar substances Isopropyl myristrate (CAS 110-27-0) and octyl oleate (CAS 2306-88-9) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification in IUCLID section 13.
The toxicity of the source substance Isopropyl myristate (CAS 110-27-0) to Pseudomonas putida was tested according to a national guideline and GLP (Coenen, 1988). After an incubation time of 18 h, no toxicity threshold could be determined, since all the measured extinction values were very close to the reference. Therefore, an EC50 (18 h) > 10 mg/L was stated based on an estimated limit of water solubility.
The results are supported by a study on the toxicity of octyl octanoate (CAS 2306-88-9) to activated sludge microorganisms. This study was performed according to OECD Guideline 209 (Hammer, 2013). Activated sludge (non-adapted) was exposed to the test substance in a static system for 3 hours, at nominal concentrations of 1000, 500, 250, 125 and 62.5 mg/L. No toxicity was observed at any of the concentrations tested, and the EC10 was determined to be > 1000 mg/L.
Based on the results of the read across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it is assumed thatFatty acids, C8-12, isopentylesterhas no inhibitory effects on aquatic microorganisms activity.
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