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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 21 - 30, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
yes (incl. certificate)
Remarks:
The Department of Health of the Government of the United Kingdom
Dissociating properties:
yes
pKa:
6.77
Temp.:
20 °C

Preliminary test results

Vol. of Titrant (mL)

pH

Mean Vol (mL)

ΔpH/ΔV

0.00

7.80

0.05

-6.20

0.10

7.18

0.15

-5.60

0.20

6.62

0.25

-8.80

0.30

5.74

0.35

-4.50

0.40

5.29

0.45

-2.90

0.50

5.00

0.55

-1.50

0.60

4.85

0.65

-0.90

0.70

4.76

0.75

-1.40

0.80

4.62

0.85

-0.60

0.90

4.56

0.90

-

Full test results

Vol. of Titrant (mL)

pH

0.00

7.60

0.05

7.07

0.10

6.77

0.15

6.63

0.20

6.42

0.25

6.10

0.30

5.69

Description of key information

pKa = 6.77 (OECD 112, titration method)

Key value for chemical safety assessment

Additional information