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EC number: 944-243-9 | CAS number: -
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- March 21 - 30, 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The Department of Health of the Government of the United Kingdom
- Dissociating properties:
- yes
- pKa:
- 6.77
- Temp.:
- 20 °C
Reference
Preliminary test results
Vol. of Titrant (mL) | pH | Mean Vol (mL) | ΔpH/ΔV |
0.00 | 7.80 | 0.05 | -6.20 |
0.10 | 7.18 | 0.15 | -5.60 |
0.20 | 6.62 | 0.25 | -8.80 |
0.30 | 5.74 | 0.35 | -4.50 |
0.40 | 5.29 | 0.45 | -2.90 |
0.50 | 5.00 | 0.55 | -1.50 |
0.60 | 4.85 | 0.65 | -0.90 |
0.70 | 4.76 | 0.75 | -1.40 |
0.80 | 4.62 | 0.85 | -0.60 |
0.90 | 4.56 | 0.90 | - |
Full test results
Vol. of Titrant (mL) | pH |
0.00 | 7.60 |
0.05 | 7.07 |
0.10 | 6.77 |
0.15 | 6.63 |
0.20 | 6.42 |
0.25 | 6.10 |
0.30 | 5.69 |
Description of key information
pKa = 6.77 (OECD 112, titration method)
Key value for chemical safety assessment
Additional information
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