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EC number: 944-243-9 | CAS number: -
GHS Rating and Calculations
Six rabbits were divided into two treatment groups: 0.1 mL of a 50% w/w solution of the test material B0010 (44% KAS paste) in distilled water was instilled into one eye each of three rabbits (Group I); a second group of three rabbits received the same treatment as Group I, followed at 4 sec by a 20 mL lukewarm tap water rinse (Group II). The eyes were examined for corneal opacity, iritis and conjunctivitis at 1 h and on Days 1, 2, 3, 4, 7, 14, 21 and 28 following treatment and were graded using Draize ocular irritation grading system.
All three eyes in Group I were assigned positive scores for corneal opacity and ulceration, iritis, conjunctival redness and chemosis. Two eyes were clear on Day 28 of the study and showed signs of eye irritation on Day 21 of the study.
Three eyes in Group II were assigned positive scores for corneal opacity. Three eyes were observed to have positive scores for conjunctival redness and two for chemosis. In addition, two eyes were assigned positive score for iritis. One eye was clear on Day 3 and two on Day 21 of the study.
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